Mitochondria and Cancer: Warburg Addressed

Why do cancers have high aerobic glycolysis?

2004 • 4,534 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Mitochondrial DNA and human evolution

1987 • 2,967 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 • 2,561 citations

Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic Neuropathy

1988 • 2,368 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma

2000 • 1,604 citations

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation

1990 • 1,456 citations

The evolution of free radicals and oxidative stress

2000 • 1,384 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

2001 • 1,082 citations

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2004 • 1,045 citations

Natural selection shaped regional mtDNA variation in humans

2002 • 1,019 citations

A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.

1990 • 981 citations

AKT plays a central role in tumorigenesis

2001 • 932 citations

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

2001 • 921 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Mutations in SDHC cause autosomal dominant paraganglioma, type 3

2000 • 877 citations

Advances in protein kinase B signalling: AKTion on multiple fronts

2004 • 828 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

mtDNA mutations increase tumorigenicity in prostate cancer

2005 • 821 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA

2004 • 793 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Mitochondrial mutations in cancer

2006 • 785 citations

[42]Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

1996 • 746 citations

Tumor Mitochondria and the Bioenergetics of Cancer Cells

2015 • 720 citations

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

2003 • 719 citations

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

1995 • 711 citations

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1998 • 676 citations

Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

2004 • 612 citations

Going APE over ref-1

2000 • 529 citations

Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease

1988 • 509 citations

Emery and Rimoin's Principles and Practice of Medical Genetics

1997 • 508 citations

Mitochondrial DNA variation in human evolution and disease

1999 • 462 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of SDHB-Associated Heritable Paraganglioma

2004 • 380 citations

High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase

1977 • 378 citations

THE METABOLISM OF TUMOURS

1931 • 372 citations

Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer

2005 • 367 citations

Glucose Catabolism in Cancer Cells

2001 • 351 citations

Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

2002 • 339 citations

Radiation of human mitochondria DNA types analyzed by restriction endonuclease cleavage patterns

1983 • 316 citations

mtDNA and the origin of Caucasians: identification of ancient Caucasian-specific haplogroups, one of which is prone to a recurrent somatic duplication in the D-loop region.

1994 • 312 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases

2003 • 284 citations

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

2005 • 275 citations

A Defect in the Cytochrome b Large Subunit in Complex II Causes Both Superoxide Anion Overproduction and Abnormal Energy Metabolism in Caenorhabditis elegans

2001 • 265 citations

Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma

2004 • 261 citations

Mitochondrial DNA G10398A Polymorphism and Invasive Breast Cancer in African-American Women

2005 • 253 citations

Mitochondrial DNA Somatic Mutations (Point Mutations and Large Deletions) and Mitochondrial DNA Variants in Human Thyroid Pathology

2002 • 250 citations

Dietary Restriction and Aging

1993 • 248 citations

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.

2001 • 245 citations

High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.

2001 • 245 citations

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.

1997 • 244 citations

The structure of human mitochondrial DNA variation

1991 • 243 citations

Glucose Catabolism in Cancer Cells.

1995 • 229 citations

Glucose Catabolism in Cancer Cells

1997 • 228 citations

Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?

2002 • 226 citations

Mitochondrial mutations in early stage prostate cancer and bodily fluids

2001 • 222 citations

Mitochondrial DNA Alterations in Cancer

2002 • 220 citations

The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants

2004 • 215 citations

Energy metabolism and aging: a lifelong study of Fischer 344 rats

1992 • 202 citations

Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.

1994 • 191 citations

Biallelic Inactivation of Fumarate Hydratase (FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors

2004 • 172 citations

Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours

2000 • 167 citations

A common mitochondrial DNA variant is associated with insulin resistance in adult life

1998 • 163 citations

Novel mitochondrial DNA deletion found in a renal cell carcinoma

1996 • 161 citations

Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma.

2002 • 159 citations

Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer

2003 • 153 citations

Glucose Metabolism in Cancer

2003 • 137 citations

High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples

2001 • 130 citations

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

1999 • 129 citations

Genetic Differences in Effects of Food Restriction on Aging in Mice

1987 • 126 citations

Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes

1990 • 123 citations

Increased levels of mitochondrial gene expression in rat fibroblast cells immortalized or transformed by viral and cellular oncogenes.

1986 • 118 citations

Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection.

2002 • 110 citations

Mitochondrial gene mutation, but not large-scale deletion, is a feature of colorectal carcinomas with mitochondrial microsatellite instability

1999 • 109 citations

Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes

1970 • 106 citations

Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single‐strand conformation analysis

1997 • 98 citations

Redox Regulation of the DNA Repair Function of the Human AP Endonuclease Ape1/ref-1

2001 • 92 citations

Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients

1995 • 84 citations

A tandem duplication in the D–loop of human mitochondrial DNA is associated with deletions in mitochondrial myopathies

1993 • 73 citations

Mitochondrial proteome: Cancer‐altered metabolism associated with cytochrome c oxidase subunit level variation

2004 • 65 citations

Glucose Metabolism in Cancer

2003 • 53 citations

Separation of cytochrome c-dependent caspase activation from thiol-disulfide redox change in cells lacking mitochondrial DNA11This article is dedicated to the memory of the late Professor Lars Ernster.

2000 • 52 citations

Somatic Mitochondrial DNA Mutations in Neurofibromatosis Type 1-Associated Tumors

2004 • 51 citations

Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis

2003 • 47 citations

Mitochondrial DNA alterations in thyroid cancer

2003 • 39 citations

Nucleotide Sequence Variation Is Frequent in the Mitochondrial DNA Displacement Loop Region of Individual Human Tumor Cells

2005 • 38 citations

Tumor-associated mutations of rat mitochondrial transfer RNA genes

1983 • 36 citations

On the InterAktion between Hexokinase and the Mitochondrion

2004 • 29 citations

Gene expression and tumor cell escape from host effector mechanisms in murine large cell lymphoma

1988 • 22 citations

Transcripts of the mitochondrial gene ND5 are overexpressed in highly metastatic murine large cell lymphoma cells.

1992 • 16 citations

Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs

2005 • 11 citations