Protection against Oxidant-Induced Apoptosis by Exogenous Glutathione in Leber Hereditary Optic Neuropathy Cybrids

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

2003 • 1,281 citations

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

2001 • 1,025 citations

Mitochondrial dysfunction as a cause of optic neuropathies

2004 • 753 citations

Glutathione metabolism in brain

2000 • 740 citations

Walsh and Hoyt's Clinical Neuro-Ophthalmology

1989 • 612 citations

Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology

1999 • 383 citations

D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

2003 • 382 citations

Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants

2003 • 349 citations

Cell signalling and the glutathione redox system

2002 • 347 citations

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

2005 • 304 citations

Inhibition of complex I of the electron transport chain causes O₂⁻·-mediated mitochondrial outgrowth

2005 • 275 citations

Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy

2002 • 267 citations

Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes

1985 • 265 citations

The systemic availability of oral glutathione

1992 • 263 citations

Functional Analysis of Lymphoblast and Cybrid Mitochondria Containing the 3460, 11778, or 14484 Leber's Hereditary Optic Neuropathy Mitochondrial DNA Mutation

2000 • 255 citations

Leber's Hereditary Optic Neuropathy (LHON) Pathogenic Mutations Induce Mitochondrial-dependent Apoptotic Death in Transmitochondrial Cells Incubated with Galactose Medium

2003 • 187 citations

Severe Impairment of Complex I–Driven Adenosine Triphosphate Synthesis in Leber Hereditary Optic Neuropathy Cybrids

2005 • 168 citations

Respiration and Growth Defects in Transmitochondrial Cell Lines Carrying the 11778 Mutation Associated with Leber's Hereditary Optic Neuropathy

1996 • 156 citations

Do Idebenone and Vitamin Therapy Shorten the Time to Achieve Visual Recovery in Leber Hereditary Optic Neuropathy?

2000 • 137 citations

Cells Bearing Mutations Causing Leber's Hereditary Optic Neuropathy Are Sensitized to Fas-induced Apoptosis

2002 • 135 citations

Biochemical features of mtDNA 14484 (ND6/m64V) point mutation associated with Leber's hereditary optic neuropathy

1999 • 134 citations

Role of Alpha-2 Agonists in Neuroprotection

2003 • 125 citations

Leber's hereditary optic neuropathy

1997 • 124 citations

MtDNA Mutations Associated with Leber′s Hereditary Optic Neuropathy: Studies on Cytoplasmic Hybrid (Cybrid) Cells

1995 • 119 citations

Caspase-independent death of Leber’s hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G

2005 • 119 citations

Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines

2004 • 117 citations

Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy

2005 • 106 citations

LEBER'S OPTIC NEUROPATHY

1979 • 106 citations

Prophylaxis for Second Eye Involvement in Leber Hereditary Optic Neuropathy: An Open-Labeled, Nonrandomized Multicenter Trial of Topical Brimonidine Purite

2005 • 97 citations

Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein

2003 • 91 citations

[28] Mitochondria-mediated transformation of human ϱ0 cells

1996 • 90 citations

Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons

2005 • 87 citations

mtDNA Mutations Confer Cellular Sensitivity to Oxidant Stress That Is Partially Rescued by Calcium Depletion and Cyclosporin A

1997 • 84 citations

In vivo skeletal muscle mitochondrial function in Leber's hereditary optic neuropathy assessed by ³¹P magnetic resonance spectroscopy

1997 • 74 citations

Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-l-carnitine to mouse fibroblasts in culture

2005 • 73 citations

The enigmatic relationship between mitochondrial dysfunction and Leber’s hereditary optic neuropathy

1999 • 72 citations

Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

2003 • 70 citations

Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA‐depleted cell lines

2004 • 56 citations

Features of Whey Protein Concentrate Supplementation in Children with Rapidly Progressive HIV Infection

2005 • 52 citations

Creatine enhances survival of glutamate‐treated neuronal/glial cells, modulates Ras/NF‐κB signaling, and increases the generation of reactive oxygen species

2004 • 40 citations

ATP depletion and caspase independent death of cybrids bearing Leber's Hereditary Optic neuropathy MTDNA mutations incubated in galactose medium. A model for endonuclease G-mediated apoptosis

2004 • 27 citations

Biochemical features of mtDNA 14484 (ND6/m64V) point mutation associated with Leber's hereditary optic neuropathy

1999 • 19 citations

Glutathione depletion in antioxidant defense of differentiated NT2-LHON cybrids

2006 • 14 citations

Similar effects of succinic acid dimethyl ester and glucose on islet calcium oscillations and insulin release

2003 • 14 citations

Leber's optic neuropathy.

1980 • 6 citations