Oncogenic Ras and its role in tumor cell invasion and metastasis

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Rho GTPases in cell biology

2002 • 4,662 citations

ras GENES

1987 • 3,818 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

Regulation of matrix metalloproteinase expression in tumor invasion

1999 • 1,503 citations

To cycle or not to cycle: a critical decision in cancer

2001 • 1,429 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Integrins and anoikis

1997 • 1,145 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

2001 • 858 citations

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

2000 • 853 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Understanding Ras: ‘it ain’t over ’til it’s over’

2000 • 785 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

1998 • 739 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

Rho GTPases: Signaling, Migration, and Invasion

2000 • 584 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Ras signalling and apoptosis

1998 • 559 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein

1999 • 527 citations

A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

2002 • 522 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK

1998 • 496 citations

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

1997 • 470 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Ras effectors

1996 • 445 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Mechanisms of regulating the Raf kinase family

2003 • 397 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

2003 • 389 citations

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

2002 • 388 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

2002 • 318 citations

Signal transduction and the Ets family of transcription factors

2000 • 317 citations

Ras and Rho regulation of the cell cycle and oncogenesis

2001 • 316 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

1993 • 281 citations

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

2002 • 278 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Breast Cancer

1992 • 249 citations

Ral-GTPases: approaching their 15 minutes of fame

2003 • 243 citations

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

1985 • 240 citations

Role of Rho family GTPases in epithelial morphogenesis

2002 • 238 citations

Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.

1998 • 238 citations

Aberrant function of the Ras signal transduction pathway in human breast cancer

1995 • 218 citations

Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype

1988 • 209 citations

Ras Family Signaling: Therapeutic Targeting

2002 • 206 citations

p38 Mitogen-Activated Protein Kinase-Dependent Activation of Protein Phosphatases 1 and 2A Inhibits MEK1 and MEK2 Activity and Collagenase 1 (MMP-1) Gene Expression

2001 • 206 citations

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.

1994 • 204 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

1998 • 196 citations

Signaling pathways in Ras-mediated tumorigenicity and metastasis

1998 • 194 citations

Regulation of Tiam1–Rac signalling

2003 • 193 citations

Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell.

1985 • 175 citations

Phase II and Pharmacodynamic Study of the Farnesyltransferase Inhibitor R115777 as Initial Therapy in Patients With Metastatic Pancreatic Adenocarcinoma

2003 • 170 citations

Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the α6β4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion

2001 • 168 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

2001 • 157 citations

R-Ras Signals through Specific Integrin α Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells

1999 • 156 citations

Ras caught in another affair: the exchange factors for Ral

1999 • 156 citations

Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro

2003 • 136 citations

Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality

1998 • 128 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

Ets up-regulates MET transcription.

1996 • 126 citations

Cell cycle: Routine role for Ras

1997 • 123 citations

Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites.

1994 • 122 citations

Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells

2000 • 121 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

Experimental metastasis in nude mice of NIH 3T3 cells containing various ras genes.

1986 • 119 citations

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase

2001 • 117 citations

A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis.

2002 • 108 citations

Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling

2002 • 106 citations

The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis

2003 • 104 citations

Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line

1989 • 103 citations

Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase

2001 • 98 citations

Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma

1999 • 94 citations

Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras‐transformed NIH 3T3 cells

1992 • 91 citations

Cell Signaling: Life or Death Decisions of Ras Proteins

2002 • 88 citations

Tissue microarray analysis of cytoskeletal actin‐associated biomarkers gelsolin and E‐cadherin in urothelial carcinoma

2002 • 86 citations

Ras superfamily monomeric G proteins in carcinoma cell motility

2002 • 84 citations

Experimental metastatic ability of H-ras-transformed NIH3T3 cells.

1985 • 83 citations

The role of Ral A in epidermal growth factor receptor-regulated cell motility.

2002 • 81 citations

p120 Catenin Is Required for Growth Factor–dependent Cell Motility and Scattering in Epithelial Cells

2003 • 79 citations

Transforming Growth Factor-β1 Promotes Invasiveness after Cellular Transformation with Activated Ras in Intestinal Epithelial Cells

2001 • 77 citations

RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases

1999 • 76 citations

Invasiveness of Transformed Human Breast Epithelial Cell Lines Is Related to Cathepsin B and Inhibited by Cysteine Proteinase Inhibitors

2003 • 70 citations

Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis

1998 • 70 citations

Pharmacologic Inhibitors of MKK1 and MKK2

2001 • 64 citations

Oncogenic Ki-ras but Not Oncogenic Ha-rasBlocks Integrin β1-Chain Maturation in Colon Epithelial Cells

1997 • 58 citations

Increased invasive, chemotactic and locomotive abilities of c-Ha-ras-transformed human breast epithelial cells.

1991 • 45 citations

v-Ha-RaS oncogene upregulates the 92-kDa type IV collagenase (MMP-9) gene by increasing cellular superoxide production and activating NF-κB

2001 • 37 citations

Inhibiting Ras Signaling in the Therapy of Breast Cancer

2003 • 34 citations

Differences in in vitro invasive capacity induced by differences in Ki‐Ras protein mutations

2001 • 33 citations

Regulation of Urokinase Receptor Transcription by Ras- and Rho-Family GTPases

2000 • 33 citations

Invasive and metastatic properties of MCF‐7 cells and ras^H‐transfected MCF‐7 cell lines

1992 • 27 citations

Induction of urokinase activity and malignant phenotype in bladder carcinoma cells after transfection of the activated Ha-ras oncogene

1989 • 26 citations

Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation.

1992 • 25 citations

The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (uPAR) gene via an AP1-dependent mechanism

2001 • 22 citations

Inhibition of collagenolytic activity relates to quantitative reduction of invasionin vitro in a c-Ha-ras transfected glial cell line

1994 • 20 citations

Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.

1990 • 18 citations

Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.

1995 • 16 citations

Collagen processing in ras-transfected mouse mammary epithelial cells

1986 • 9 citations

Transfection of normal and transformed hamster cerebral cortex glial cells with activated c-H-ras-1 results in the acquisition of a diffusely invasive phenotype.

1989 • 9 citations