Genome instability and oncogenesis

The Hallmarks of Cancer

2000 • 27,569 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

The multifaceted mismatch-repair system

2006 • 1,264 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

2002 • 845 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

The complexity of p53 stabilization and activation

2006 • 670 citations

The P53 pathway: what questions remain to be explored?

2006 • 640 citations

Inflammation as a tumor promoter in cancer induction

2004 • 608 citations

The role of double-strand break repair — insights from human genetics

2005 • 560 citations

Role of nitric oxide in carcinogenesis and tumour progression

2001 • 552 citations

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

2006 • 544 citations

p53: traffic cop at the crossroads of DNA repair and recombination

2005 • 529 citations

The dark side of Ras: regulation of apoptosis

2003 • 430 citations

Cancer in xeroderma pigmentosum and related disorders of DNA repair

2005 • 422 citations

Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes

2004 • 379 citations

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

2004 • 374 citations

Genomic instability — the engine of tumorigenesis?

2003 • 330 citations

Centrosome amplification, chromosome instability and cancer development

2005 • 310 citations

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

2006 • 238 citations

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

2004 • 221 citations

ATM signaling and genomic stability in response to DNA damage

2004 • 209 citations

Nitrative DNA damage in inflammation and its possible role in carcinogenesis

2005 • 198 citations

Chfr is required for tumor suppression and Aurora A regulation

2005 • 194 citations

HBV induced carcinogenesis

2005 • 179 citations

Cell Cycle Features of Primate Embryonic Stem Cells

2005 • 175 citations

Characterization of Tumor-associated Chk2 Mutations

2001 • 172 citations

A Novel Human p53 Isoform Is an Essential Element of the ATR-Intra-S Phase Checkpoint

2005 • 144 citations

Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

2007 • 138 citations

p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells

2006 • 124 citations

Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.

2002 • 120 citations

Mechanisms of DNA damage recognition and strand discrimination in human nucleotide excision repair

2004 • 119 citations

Mutator phenotype of BCR – ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase β

1999 • 105 citations

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis

2006 • 103 citations

Ras-mediated Loss of the Pro-apoptotic Response Protein Par-4 Is Mediated by DNA Hypermethylation through Raf-independent and Raf-dependent Signaling Cascades in Epithelial Cells

2005 • 94 citations

Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

2005 • 94 citations

Some p53-binding proteins that can function as arbiters of life and death

2006 • 91 citations

Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations

2006 • 91 citations

BRCA1 in hormonal carcinogenesis: basic and clinical research

2005 • 88 citations

Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-α transgenic mouse model of liver cancer

2004 • 84 citations

Up-Regulation of the Error-Prone DNA Polymerase κ Promotes Pleiotropic Genetic Alterations and Tumorigenesis

2005 • 81 citations

BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription

2003 • 78 citations

DNA Damage-induced Down-regulation of Human Cdc25C and Cdc2 Is Mediated by Cooperation between p53 and Maintenance DNA (Cytosine-5) Methyltransferase 1

2006 • 68 citations

C/EBPα Is a DNA Damage-Inducible p53-Regulated Mediator of the G₁ Checkpoint in Keratinocytes

2004 • 67 citations

Identification of Domains of BRCA1 Critical for the Ubiquitin-Dependent Inhibition of Centrosome Function

2006 • 58 citations

Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint

2006 • 55 citations

Considering the cancer consequences of altered DNA polymerase function

2003 • 55 citations

Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC

2005 • 54 citations

Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability?

2005 • 50 citations

Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide

2005 • 45 citations

HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal‐regulated kinase 1/2 pathway

2004 • 45 citations

The Epithelial Cell Transforming Sequence 2, a Guanine Nucleotide Exchange Factor for Rho GTPases, Is Repressed by p53 via Protein Methyltransferases and Is Required for G1-S Transition

2006 • 42 citations

Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase κ

2005 • 41 citations

p53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints

1999 • 40 citations

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

2005 • 35 citations

Cell type-specific effects of asbestos on intracellular ROS levels, DNA oxidation and G1 cell cycle checkpoint

2004 • 34 citations

Leukemia and lymphoma: a cost of doing business for adaptive immunity

2006 • 32 citations

Transfection of K-rasAsp12 cDNA markedly elevates IL-1β- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells

2003 • 21 citations

Activation of Ras-Ral Pathway Attenuates p53-independent DNA Damage G2 Checkpoint

2004 • 19 citations

Molecular Mechanisms of Carcinogenesis

2005 • 12 citations