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Rho GTPases and the Actin Cytoskeleton

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Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

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Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

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Small GTP-Binding Proteins

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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

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Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

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A causal role for E-cadherin in the transition from adenoma to carcinoma

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Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

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Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Rac Downregulates Rho Activity

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Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

1998 • 834 citations

Regulation of Cadherin Adhesive Activity

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The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Integrin signaling and cell growth control

1998 • 655 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

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P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

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Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

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Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

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The E-cadherin–catenin complex in tumour metastasis

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Insulin-like growth factor physiology and cancer risk

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Cytomechanics of cadherin-mediated cell—cell adhesion

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Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin

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Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

1993 • 248 citations

Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors

1998 • 239 citations

Rho family proteins in cell adhesion and cell migration

2000 • 239 citations

p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells

1999 • 229 citations

The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells

1996 • 223 citations

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

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Epithelial (E‐) and placentae (P‐) cadherin cell adhesion molecule expression in breast carcinoma

1993 • 200 citations

Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells.

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E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms

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Curbing the nuclear activities of β‐catenin

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The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components

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The Novel Catenin p120casBinds Classical Cadherins and Induces an Unusual Morphological Phenotype in NIH3T3 Fibroblasts

1996 • 153 citations

Overexpressed IGF-I Receptors Reduce Estrogen Growth Requirements, Enhance Survival, and Promote E-Cadherin-Mediated Cell–Cell Adhesion in Human Breast Cancer Cells

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Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

1993 • 122 citations

Expression of E-Cadherin in Normal, Benign, and Malignant Tissues of Female Genital Organs

1992 • 116 citations

Cell adhesion and Rho small GTPases

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Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer

1994 • 98 citations

Insulin-like growth factors and breast cancer

1995 • 96 citations

Involvement of dileucine motifs in the internalization and degradation of the insulin receptor

1994 • 90 citations

Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells

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Control over Wnt target gene expression

2000 • 45 citations

Structural analysis of the role of the p3 subunit of the αVβ3 integrin in IGF-I signaling

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Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of αv integrins

2000 • 39 citations