Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

2000 • 195 citations

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

1999 • 180 citations

Ubiquitin-mediated degradation of active Src tyrosine kinase

1999 • 159 citations

Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species

2000 • 158 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Cytoskeletal Protein PSTPIP1 Directs the PEST-Type Protein Tyrosine Phosphatase to the c-Abl Kinase to Mediate Abl Dephosphorylation

2000 • 125 citations

Ubiquitin-dependent degradation of active Src

1999 • 122 citations

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

1998 • 117 citations

The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation

1997 • 56 citations

Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.

1995 • 52 citations

Oncogenic Activation of c-ABL by Mutation within Its Last Exon

1993 • 51 citations

Oncogenic activation of c-ABL by mutation within its last exon.

1993 • 38 citations