The role of insulin receptor signaling in the brain

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 • 1,393 citations

Sniffing neuropeptides: a transnasal approach to the human brain

2002 • 1,243 citations

Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

2004 • 1,188 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

1998 • 728 citations

Insulin Signaling in Health and Disease

2003 • 700 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

1997 • 631 citations

Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

2004 • 609 citations

Role for neuronal insulin resistance in neurodegenerative diseases

2004 • 601 citations

Glucose and Osmosensitive Neurones of the Rat Hypothalamus

1969 • 588 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

1998 • 550 citations

Clearing the Brain's Amyloid Cobwebs

2001 • 538 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

1992 • 533 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

2000 • 501 citations

The source of cerebral insulin

2004 • 473 citations

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

2003 • 468 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

2003 • 458 citations

Serum insulin-like growth factor I regulates brain amyloid-β levels

2002 • 440 citations

Quantitative study of insulin secretion and clearance in normal and obese subjects.

1988 • 438 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study

1997 • 366 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

1997 • 357 citations

Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients

1990 • 340 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

1979 • 319 citations

Central melanocortin receptors regulate insulin action

2001 • 317 citations

Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

1999 • 315 citations

Insulin and the Blood-Brain Barrier

2003 • 314 citations

Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action

1997 • 311 citations

Improving Influence of Insulin on Cognitive Functions in Humans

2001 • 309 citations

Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

2004 • 304 citations

Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

2002 • 286 citations

Insulin in the Cerebrospinal Fluid

1967 • 283 citations

Brain glucose sensing and body energy homeostasis: role in obesity and diabetes

1999 • 265 citations

Insulin and Leptin as Adiposity Signals

2004 • 263 citations

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

1994 • 257 citations

INSULIN ACTION IN THE NORMAL AND POLYCYSTIC OVARY

1999 • 256 citations

Hypothalamic control of energy balance: different peptides, different functions

2004 • 237 citations

Brain insulin: regulation, mechanisms of action and functions.

2003 • 230 citations

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

2003 • 218 citations

Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

2003 • 217 citations

Relationship between plasma and cerebrospinal fluid insulin levels of dogs.

1977 • 216 citations

Why is learning and memory dysfunction in Type 2 diabetes limited to older adults?

2000 • 188 citations

Central nervous system effects of intranasally administered insulin during euglycemia in men.

1999 • 185 citations

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

2003 • 176 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1992 • 172 citations

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

2002 • 171 citations

Gonadotropin-Releasing Hormone Secretion from Hypothalamic Neurons: Stimulation by Insulin and Potentiation by Leptin

2003 • 162 citations

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

1977 • 157 citations

A Disturbance in the Neuronal Insulin Receptor Signal Transduction in Sporadic Alzheimer's Disease

1999 • 154 citations

Phenotype and genotype in polycystic ovary syndrome

2001 • 149 citations

Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway

2001 • 146 citations

Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line

2000 • 141 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 134 citations

Differential effects of melanocortin peptides on neural melanocortin receptors.

1994 • 127 citations

Immunocytochemical Detection of Insulin in Rat Hypothalamus and Its Possible Uptake from Cerebrospinal Fluid^*

1983 • 121 citations

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1995 • 115 citations

Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat.

1990 • 109 citations

PHYSIOLOGY OF GLUCOSE COUNTERREGULATION TO HYPOGLYCEMIA

1999 • 97 citations

Mechanism of neurofibrillary degeneration in Alzheimer's disease

1994 • 70 citations

Anabolic neuropeptides

2004 • 68 citations

Effects of age on working memory: an event-related potential study

1999 • 51 citations

Effect of Centrally Administered Insulin on Gonadotropin-Releasing Hormone Neuron Activity and Luteinizing Hormone Surge in the Diabetic Female Rat

2002 • 47 citations

Chronic intrahypothalamic insulin infusion in the rat: Behavioral specificity

1993 • 45 citations

Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice

1999 • 41 citations

Insulin and raclopride combine to decrease short-term intake of sucrose solutions

2000 • 37 citations

Neurotransmitter Transporters: Target for Endocrine Regulation

1999 • 31 citations

Single-trial latency variability of auditory evoked potentials may indicate immediate memory in the albino rat

2003 • 5 citations