Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Spatial localization does not require the presence of local cues

1981 • 2,665 citations

Alzheimer Disease in the US Population

2003 • 2,179 citations

15-year longitudinal study of blood pressure and dementia

1996 • 1,706 citations

Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial

1998 • 1,429 citations

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 • 1,393 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

2001 • 990 citations

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 • 984 citations

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

2002 • 853 citations

Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

1997 • 683 citations

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 • 679 citations

Hypertension Is Related to Cognitive Impairment

1998 • 631 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

1993 • 559 citations

Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome

2003 • 496 citations

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

2001 • 479 citations

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

2000 • 466 citations

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

2000 • 366 citations

Insulin Resistance Syndrome Predicts the Risk of Coronary Heart Disease and Stroke in Healthy Middle-Aged Men

2000 • 359 citations

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

2003 • 321 citations

A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling

1999 • 306 citations

Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3

2001 • 288 citations

Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo

2003 • 285 citations

Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

2001 • 260 citations

Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months

2002 • 234 citations

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

2000 • 233 citations

Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice

2002 • 218 citations

Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study

1997 • 209 citations

Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency

2003 • 182 citations

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

1997 • 180 citations

Signalling through IGF-I and insulin receptors: where is the specificity?

2002 • 163 citations

Estrogen and cognition: Applying preclinical findings to clinical perspectives

2003 • 156 citations

Dietary Links to Alzheimer's Disease: 1999 Update*

1999 • 132 citations

Cyclooxygenase-2 Promotes Amyloid Plaque Deposition in a Mouse Model of Alzheimer's Disease Neuropathology

2002 • 125 citations

Molecular mechanisms of insulin receptor substrate protein‐mediated modulation of insulin signalling

2003 • 123 citations

The optical rotator

1997 • 121 citations

Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet.

2002 • 115 citations

Hypothermia in mice tested in Morris water maze

2003 • 114 citations

Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice

2000 • 112 citations

Cardiovascular and Other Risk Factors for Alzheimer's Disease and Vascular Dementia

2000 • 111 citations

Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease

2002 • 107 citations

In Vivo Regulation of Phosphoinositide 3-Kinase in Retina through Light-induced Tyrosine Phosphorylation of the Insulin Receptor β-Subunit

2002 • 80 citations

Numbers of Meynert and layer IVB cells in area V1: A stereologic analysis in young and aged macaque monkeys

2000 • 74 citations

Aberrant Stress Response Associated with Severe Hypoglycemia in a Transgenic Mouse Model of Alzheimer's Disease

1999 • 71 citations

Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life

2003 • 50 citations

Are vascular factors involved in Alzheimer’s disease? Facts and theories

1999 • 25 citations

ALZHEIMER'S DISEASE AND VASCULAR FACTORS: FACTS AND THEORIES

2002 • 24 citations

Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity.

2003 • 19 citations

Coping behavior, punishment and gastric secretion in the rat

1975 • 1 citations

Deleted Work

1955 • 0 citations