Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

Positional cloning of the mouse obese gene and its human homologue

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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

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The Continuing Epidemics of Obesity and Diabetes in the United States

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Getting Formal with Dopamine and Reward

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The Spread of the Obesity Epidemic in the United States, 1991-1998

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

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Brain Dopamine and Reward

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Food reward: Brain substrates of wanting and liking

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The Neuroscience of Natural Rewards: Relevance to Addictive Drugs

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NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

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Neurobehavioural mechanisms of reward and motivation

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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

2002 • 1,055 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

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The dopamine hypothesis of reward: past and current status

1999 • 981 citations

Brain Reward Circuitry

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Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

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Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

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Opioid modulation of taste hedonics within the ventral striatum

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Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat

2003 • 453 citations

Modulation of Brain Reward Circuitry by Leptin

2000 • 411 citations

Genetic approaches to studying energy balance: perception and integration

2002 • 401 citations

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight

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Neuropeptide Y Stimulates Feeding but Inhibits Sexual Behavior in Rats*

1985 • 397 citations

Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

1991 • 386 citations

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

2002 • 374 citations

Analysis of the microstructure of the rhythmic tongue movements of rats ingesting maltose and sucrose solutions.

1992 • 363 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

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Impaired transport of leptin across the blood-brain barrier in obesity☆

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Insulin gene expression and insulin synthesis in mammalian neuronal cells.

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Effects of parabiosis of normal with genetically diabetic mice

1969 • 326 citations

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels

1979 • 324 citations

Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.

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Localization and Characterization of Insulin Receptors in Rat Brain and Pituitary Gland Usingin VitroAutoradiography and Computerized Densitometry*

1987 • 319 citations

Regulation of Food Intake and Obesity

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Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

2000 • 314 citations

Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior

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Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes

1997 • 298 citations

Augmentation of drug reward by chronic food restriction

2002 • 296 citations

Dopaminergic correlates of motivated behavior: importance of drive

1995 • 296 citations

Localization of drug reward mechanisms by intracranial injections

1992 • 274 citations

Increased Drug-Reinforced Behavior due to Food Deprivation

1984 • 271 citations

Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity

2002 • 252 citations

The NPY/AgRP neuron and energy homeostasis

2001 • 248 citations

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward

1995 • 233 citations

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

1986 • 230 citations

The dopamine transporter: A crucial component regulating dopamine transmission

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Microdialysis Studies of Brain Norepinephrine, Serotonin, and Dopamine Release During Ingestive Behavior Theoretical and Clinical Implicationsa

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Central leptin modulates behavioral and neural responsivity to CCK

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Reduction of food intake and body weight by chronic intraventricular insulin infusion

1984 • 207 citations

Opioids and food intake: distributed functional neural pathways?

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Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.

1990 • 188 citations

Leptin Attenuates Acute Food Deprivation-Induced Relapse to Heroin Seeking

2001 • 184 citations

Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. ‘natural’ reinforcement

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Now you see it...

2002 • 181 citations

Increased Hypothalamic Content of Preproneuropeptide-Y Messenger Ribonucleic Acid in Streptozotocin-Diabetic Rats*

1990 • 180 citations

Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra

1994 • 171 citations

Neuropeptides and obesity

2000 • 171 citations

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

2002 • 171 citations

Insulin modulates leptin‐induced STAT3 activation in rat hypothalamus

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Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

1986 • 167 citations

Metering of intravenous versus oral nutrients and regulation of energy balance

1976 • 165 citations

Regulation of food intake and body weight by insulin

1981 • 164 citations

Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat

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Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice

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Acute third ventricular administration of insulin decreases food intake in two paradigms

2002 • 148 citations

Food Deprivation Decreases mRNA and Activity of the Rat Dopamine Transporter

1998 • 145 citations

Opioid receptor involvement in the effect of AgRP- (83–132) on food intake and food selection

2001 • 144 citations

Intracerebroventricular infusions of 3-OHB and insulin in a rat model of dietary obesity

1988 • 132 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 130 citations

Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin**This work was supported by grants from the NIH (DK-12829, DK-52989, and NS-32272) and by the Royalty Research Fund, the Diabetes Endocrinology Research Center, and the Clinical Nutrition Research Unit of the University of Washington.

2000 • 128 citations

Leptin reverses sucrose-conditioned place preference in food-restricted rats

2001 • 128 citations

Feeding, drug abuse, and the sensitization of reward by metabolic need

1996 • 125 citations

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

1992 • 125 citations

Functional significance of mesolimbic dopamine

1995 • 121 citations

Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats

1990 • 113 citations

Leptin transport across the blood–brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene

2002 • 111 citations

Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat.

1990 • 109 citations

The corticotropin-releasing hormone system in the regulation of energy balance in obesity

2000 • 103 citations

Characterization and Regulation of Insulin Receptors in Rat Brain

1984 • 101 citations

Intraventricular insulin and the level of maintained body weight in rats.

1995 • 100 citations

Dynamic regulation of leptin entry into brain by the blood–brain barrier

2000 • 95 citations

Acute changes in the response to peripheral leptin with alteration in the diet composition

2001 • 95 citations

Intraventricular insulin and the level of maintained body weight in rats.

1995 • 95 citations

Similar effect of raclopride and reduced sucrose concentration on the microstructure of sucrose sham feeding

1990 • 93 citations

Oligosaccharide Heterogeneity of Insulin Receptors. Comparison of N-Linked Glycosylation of Insulin Receptors in Adipocytes and Brain*

1986 • 90 citations

Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: Evidence against involvement in satiety

1983 • 89 citations

Brain and Liver Insulin Binding Is Decreased in Zucker Rats Carrying the ’fa’ Gene*

1985 • 89 citations

Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies

2001 • 88 citations

Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues

1990 • 86 citations

Reduced Effect of Experimental Peripheral Hyperinsulinemia to Elevate Cerebrospinal Fluid Insulin Concentrations of Obese Zucker Rats*

1987 • 85 citations

Amygdala-lesion obesity: what is the role of the various amygdaloid nuclei?

2000 • 78 citations

Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

1986 • 68 citations

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

1985 • 68 citations

Central insulin and macronutrient intake in the rat

1996 • 67 citations

Insulin, Neuropeptide Y, and Food Intake

1993 • 60 citations

Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.

1995 • 60 citations

Insulin Receptors Mediate Growth Effects in Cultured Fetal Neurons. I. Rapid Stimulation of Protein Synthesis*

1989 • 58 citations

Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice

2000 • 57 citations

Insulin and IGF‐I Receptor Signaling in Cultured Neurons^a

1993 • 55 citations

Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.

1995 • 55 citations

Brain reward circuitry and the regulation of energy balance

2001 • 54 citations

Effect of diet-induced obesity and experimental hyperinsulinemia on insulin uptake into CSF of the rat

1993 • 52 citations

Hypoinsulinemia may mediate the lowering of self-stimulation thresholds by food restriction and streptozotocin-induced diabetes

2000 • 50 citations

Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats

2002 • 49 citations

Different effects of short- and long-term treatment with imipramine on the apomorphine- and food-induced place preference conditioning in rats

1988 • 48 citations

RAPID TRANSPORT OF BIOLOGICALLY INTACT INSULIN THROUGH CULTURED ENDOTHELIAL CELLS

1984 • 43 citations

Insulin Receptors Mediate Growth Effects in Cultured Fetal Neurons. II. Activation of a Protein Kinase that Phosphorylates Ribosomal Protein S6*

1989 • 43 citations

Insulin and insulin-like growth factor I induce c-fos expression in postmitotic neurons by a protein kinase C-dependent pathway

1993 • 40 citations

Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture

1985 • 39 citations

In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier

2001 • 39 citations

Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture

1989 • 38 citations

Insulin and raclopride combine to decrease short-term intake of sucrose solutions

2000 • 37 citations

Endocrine regulation of food intake and body weight

1996 • 31 citations

Obesity-inducing lesions of the central nervous system alter leptin uptake by the blood-brain barrier

2001 • 29 citations

Neural substrate for an integrated metabolic control of feeding behavior

1999 • 29 citations

Adiposity signals and brain reward mechanisms

2000 • 29 citations

Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines

1997 • 28 citations

Brain insulin binding is decreased in Wistar Kyoto rats carrying the ‘fa’ gene

1986 • 27 citations

Insulin and Insulin-Like Growth Factors Stimulatein VivoReceptor Autophosphorylation and Tyrosine Phosphorylation of a 70K Substrate in Cultured Fetal Chick Neurons*

1991 • 23 citations

Orexins (hypocretins): novel hypothalamic peptides with divergent functions

2000 • 22 citations

Insulin stimulates inositol incorporation in hippocampus of lean but not obese Zucker rats

1990 • 18 citations

cDNA Sequence Analysis of the Human Brain Insulin Receptor

1995 • 16 citations

Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture

1989 • 12 citations

Deleted Work

1955 • 0 citations