Insulin and Leptin as Adiposity Signals

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Dietary fat intake does affect obesity!

1998 • 1,150 citations

The Need to Feed

2002 • 1,089 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Leptin Regulation of Neuroendocrine Systems

2000 • 769 citations

Effect of fasting on serum leptin in normal human subjects.

1996 • 744 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormonein Vivo

1998 • 555 citations

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

2003 • 553 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

1992 • 533 citations

Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats

1997 • 522 citations

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

1996 • 517 citations

Diet-induced adipocyte number increase in adult rats: a new model of obesity.

1978 • 498 citations

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

1993 • 479 citations

Quantitative study of insulin secretion and clearance in normal and obese subjects.

1988 • 438 citations

Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

1995 • 434 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss.

1996 • 388 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Effect of fasting on serum leptin in normal human subjects

1996 • 361 citations

Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

2000 • 360 citations

The Central Melanocortin System and Energy Homeostasis

1999 • 349 citations

Insulin in the Brain

1987 • 340 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

Insulin and the Blood-Brain Barrier

2003 • 314 citations

Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet

1972 • 312 citations

Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism

1994 • 303 citations

Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting

1997 • 299 citations

Dietary fat, genetic predisposition, and obesity: lessons from animal models

1998 • 296 citations

The Molecular Genetics of Rodent Single Gene Obesities

1997 • 293 citations

Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women

1998 • 271 citations

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

1996 • 257 citations

The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)

1993 • 250 citations

The role of dietary fat in obesity.

1997 • 237 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss

1996 • 222 citations

Role of the CNS Melanocortin System in the Response to Overfeeding

1999 • 211 citations

Regulated Expression and Subcellular Localization of Syndecan Heparan Sulfate Proteoglycans and the Syndecan-Binding Protein CASK/LIN-2 during Rat Brain Development

1999 • 210 citations

Transgenic Expression of Syndecan-1 Uncovers a Physiological Control of Feeding Behavior by Syndecan-3

2001 • 210 citations

Heritable variation in food preferences and their contribution to obesity.

1997 • 191 citations

Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats

1997 • 188 citations

Persistent obesity in rats following a period of consumption of a mixed, high energy diet.

1980 • 185 citations

Metabolic hormones and regulation of body weight.

1974 • 185 citations

Obesity, diabetes and the central nervous system

1998 • 185 citations

Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1

1999 • 181 citations

Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion

1994 • 180 citations

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

1998 • 179 citations

A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

2000 • 178 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1992 • 172 citations

The Melanocortin Receptors

2000 • 168 citations

Central insulin enhances sensitivity to cholecystokinin

1995 • 168 citations

Metering of intravenous versus oral nutrients and regulation of energy balance

1976 • 165 citations

Acetylation alters the feeding response to MSH and beta-endorphin

1989 • 163 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

1998 • 163 citations

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

1977 • 157 citations

Obesity, Diabetes and Functions for Proopiomelanocortin-derived Peptides

1997 • 152 citations

Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression

2000 • 149 citations

Acute third ventricular administration of insulin decreases food intake in two paradigms

2002 • 148 citations

Dynamics of Recovery of Body Composition After Overfeeding, Food Restriction or Starvation of Mature Female Rats

1986 • 147 citations

Role of dietary fat in calorie intake and weight gain

1992 • 146 citations

The evaluation of insulin as a metabolic signal influencing behavior via the brain

1996 • 138 citations

Development of dietary obesity in rats: influence of amount and composition of dietary fat.

1992 • 138 citations

Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat

1992 • 134 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 130 citations

Melanocortin Receptors, The

2000 • 130 citations

Role of the brain in energy balance and obesity

1996 • 115 citations

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1995 • 115 citations

Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat.

1990 • 109 citations

Neuropeptidergic regulation of feeding behavior

1993 • 94 citations

Neuropeptide Y fails to increase intraoral intake in rats

1995 • 81 citations

An energy sensor for control of energy intake

1997 • 80 citations

Elevated insulin and satiety in obese and normal-weight rats

1982 • 71 citations

Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat

1999 • 60 citations

Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.

1995 • 60 citations

A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents.

1995 • 58 citations

Probing the causes of high-fat diet hyperphagia: A mechanistic and behavioral dissection

1996 • 57 citations

Molecular and Behavioral Interactions Between Central Melanocortins and Cocaine

2003 • 57 citations

Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.

1995 • 55 citations

Effect of heparin‐binding growth‐associated molecule (HB‐GAM) on synaptic transmission and early LTP in rat hippocampal slices

1998 • 54 citations

Intracellular pathways of insulin transport across vascular endothelial cells

1988 • 53 citations

Effects of acute “binge” cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin‐releasing hormone receptor mRNA levels in the striatum and hypothalamic–pituitary–adrenal axis of mu‐opioid receptor knockout mice

2002 • 39 citations

Genes Versus Environment: The relationship between dietary fat and total and central abdominal fat

1998 • 37 citations

Alcohol-preferring AA rats show a derangement in their central melanocortin signalling system

2002 • 34 citations

Central Nervous System Effects of Leptin

1998 • 34 citations

Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions

1992 • 30 citations

Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women

1996 • 30 citations

Changes in feeding efficiency and carcass composition in rats on repeated high-fat feedings.

1989 • 23 citations

GENETICS OF OBESITY IN HUMANS AND ANIMAL MODELS

1996 • 19 citations

Molecular characterization of the mouse agouti locus

1993 • 19 citations

Deleted Work

1955 • 0 citations