A Novel Tumor-Specific Replication-Restricted Adenoviral Vector for Gene Therapy of Hepatocellular Carcinoma

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.

1997 • 589 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Continuous Subcultivation of Epithelial-like Cells from Normal Human Tissues.

1954 • 303 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

Gene therapy: designer promoters for tumour targeting

2000 • 222 citations

Gap junction function and cancer.

1993 • 214 citations

Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy

1996 • 200 citations

Emergence of Early Region 1-Containing Replication-Competent Adenovirus in Stocks of Replication-Defective Adenovirus Recombinants (ΔE1 + ΔE3) During Multiple Passages in 293 Cells

1994 • 193 citations

Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

1991 • 187 citations

α-fetoprotein monitoring in chinese patients with chronic hepatitis B virus infection: Role in the early detection of hepatocellular carcinoma

1989 • 185 citations

Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression.

1995 • 177 citations

Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.

1995 • 163 citations

Functional Analysis of Adenovirus-5 Host-range Deletion Mutants Defective for Transformation of Rat Embryo Cells

1980 • 162 citations

Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector.

1996 • 127 citations

Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium.

1984 • 127 citations

A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.

1991 • 125 citations

Establishment and some biological characteristics of human hepatoma cell lines.

1975 • 114 citations

Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers.

1984 • 94 citations

Effect of Herpes Simplex Virus Thymidine Kinase Expression Levels on Ganciclovir-Mediated Cytotoxicity and the “Bystander Effect”

1995 • 92 citations

A Novel, Conditionally Replicative Adenovirus for the Treatment of Breast Cancer That Allows Controlled Replication of E1a-Deleted Adenoviral Vectors

2000 • 84 citations

Adenovirus E1A under the control of heterologous promoters: Wide variation in E1A expression levels has little effect on virus replication

1990 • 77 citations

Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.

1995 • 75 citations

Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation.

1991 • 62 citations

Prevention of Immune Reactions Triggered by First-Generation Adenoviral Vectors by Monoclonal Antibodies and CTLA4Ig

1996 • 59 citations

transE1 Component Requirements for Maximal Replication of E1-Defective Recombinant Adenovirus

1998 • 27 citations

Cancer gene therapy: developments to 2000

2000 • 14 citations

Tumor vaccines

1991 • 14 citations

The activation and silencing of gene transcription in the liver.

1991 • 11 citations

Hammerhead Ribozymes as Therapeutic Agents for Bladder Cancer

2000 • 6 citations