p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

1998 • 436 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Complex structure and regulation of the P16 (MTS1) locus.

1995 • 402 citations

Modelling the risk of adult T‐cell leukemia/lymphoma in persons infected with human T‐lymphotropic virus type I

1989 • 391 citations

Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection

1995 • 373 citations

Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.

1983 • 354 citations

A novel p16INK4A transcript.

1995 • 348 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

The First Human Retrovirus

1986 • 168 citations

A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

1995 • 135 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations

1992 • 132 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T‐cell leukemia‐lymphoma virus (HTLV)

1983 • 111 citations

Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.

1993 • 107 citations

Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases

1997 • 103 citations

Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1

1997 • 81 citations

A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

1998 • 67 citations

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

1997 • 40 citations

Short Communication: Deletion of the p16^INK4AGene inex VivoAcute Adult T Cell Lymphoma/Leukemia Cells and Methylation of the p16^INK4APromoter in HTLV Type I-Infected T Cell Lines

2000 • 22 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 12 citations