Ligand-Dependent Regulation of Plasmid-Based Transgene Expression in Vivo

A regulatory system for use in gene transfer.

1994 • 434 citations

Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone

1991 • 385 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

1999 • 308 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

Transcriptional Regulation of Mammalian Genes in Vivo

1997 • 244 citations

Ligand-inducible and liver-specific target gene expression in transgenic mice

1997 • 234 citations

Mifepristone (RU 486) -- A Modulator of Progestin and Glucocorticoid Action

1993 • 215 citations

Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood.

1996 • 199 citations

Expression of Naked Plasmid DNA Injected into the Afferent and Efferent Vessels of Rodent and Dog Livers

1997 • 187 citations

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

1998 • 139 citations

Control of Erythropoietin Delivery by Doxycycline in Mice After Intramuscular Injection of Adeno-Associated Vector

1998 • 133 citations

Regulation of gene expression in vivo following transduction by two separate rAAV vectors

1998 • 112 citations

Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator

1997 • 96 citations

Chemiluminescence: sensitive detection technology for reporter gene assays

1996 • 83 citations

Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system

1996 • 76 citations

Drug inducible transgene expression in brain using a herpes simplex virus vector

1998 • 69 citations

Transcriptional control: an essential component of cancer gene therapy strategies?

2000 • 58 citations

Systemic Effect of Human Growth Hormone after Intramuscular Injection of a Single Dose of a Muscle-Specific Gene Medicine

1998 • 53 citations

Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle

1995 • 53 citations

Novel, high expressing and antibiotic-controlled plasmid vectors designed for use in gene therapy.

1996 • 51 citations

Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research

2000 • 46 citations

Tetracycline-responsive gene expression in mouse brain after amplicon-mediated gene transfer

1997 • 42 citations