Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries*

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

1999 • 316 citations

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases

2000 • 255 citations

Mammosomatotropes: Presence and Functions in Normal and Neoplastic Pituitary Tissue*

1991 • 214 citations

Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements.

1989 • 176 citations

Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus.

1994 • 167 citations

Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors.

1997 • 157 citations

Estrogen receptor-β mRNA variants in human and murine tissues

1998 • 133 citations

Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3

1992 • 123 citations

CLINICAL EVALUATION OF A TWO‐SITE IMMUNORADIOMETRIC ASSAY FOR ADRENOCORTICOTROPIC IN UNEXTRACTED HUMAN PLASMA USING MONOCLONAL ANTIBODIES

1987 • 112 citations

Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.

1999 • 110 citations

Protocols for gene transfer in neuroscience : towards gene therapy of neurological disorders

1996 • 96 citations

Viral vectors for gene delivery and gene therapy within the endocrine system

2000 • 85 citations

Regulatory elements controlling pituitary-specific expression of the human prolactin gene.

1990 • 79 citations

Dynamic Changes in Prolactin Promoter Activation in Individual Living Lactotrophic Cells

1998 • 79 citations

Multihormonal regulation of the human prolactin gene expression from 5000 bp of its upstream sequence

1991 • 78 citations

Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus-contaminating recombinant adenovirus stocks

1996 • 77 citations

Targeted Expression of Toxic Genes Directed by Pituitary Hormone Promoters: A Potential Strategy for Adenovirus-Mediated Gene Therapy of Pituitary Tumors1

1999 • 70 citations

Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors.

1997 • 69 citations

Adenovirus-Mediated Herpes Simplex Virus Type-1 Thymidine Kinase Gene Therapy Suppresses Oestrogen-Induced Pituitary Prolactinomas*

2000 • 57 citations

Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK

2000 • 48 citations

Expression of Transgenes in Normal and Neoplastic Anterior Pituitary Cells Using Recombinant Adenoviruses: Long Term Expression, Cell Cycle Dependency, and Effects on Hormone Secretion*

1997 • 46 citations

FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors

1998 • 36 citations

Gene therapy strategies for the treatment of pituitary tumours

1999 • 30 citations

Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells

1998 • 22 citations

Cell-type specific expression in the pituitary: physiology and gene therapy

1999 • 22 citations

Cell proliferation and death in the irradiated pituitary gland and its modification by growth stimulants

1997 • 13 citations