Response of heat shock element within the human HSP70 promoter to mutated p53 genes.

Antibodies, a laboratory manual

1989 • 12,929 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

1993 • 361 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

The tumore suppressor p53

1993 • 336 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

1992 • 247 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

1992 • 237 citations

Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.

1985 • 227 citations

The DNA-Binding Activity of the Human Heat Shock Transcription Factor Is Regulated In Vivo by hsp70

1993 • 207 citations

The cellular oncogene p53 can be activated by mutagenesis

1985 • 181 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1992 • 161 citations

Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

1991 • 159 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment.

1990 • 127 citations

Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species

1993 • 123 citations

Mouse Heat Shock Transcription Factors 1 and 2 Prefer a Trimeric Binding Site but Interact Differently with the HSP70 Heat Shock Element

1993 • 109 citations

The p53 tumor‐suppressor gene and ras oncogene mutations in oral squamous‐cell carcinoma

1992 • 105 citations

Repression of the basal c-fos promoter by wild-type p53

1992 • 92 citations

Chromosomal location of human genes encoding major heat-shock protein HSP70

1987 • 77 citations

Expression of heat shock proteins in human lung and lung cancers.

1994 • 56 citations

Possible cytoskeletal association of 69,000- and 68,000-dalton heat shock proteins and structural relations among heat shock proteins in murine mastocytoma cells.

1986 • 46 citations

Analysis of heat shock element recognition by saturation mutagenesis of the human HSP70.1 gene promoter.

1993 • 41 citations

Translocation of hsp-70 and Protein Synthesis during Continuous Heating at Mild Temperatures in HeLa Cells

1991 • 39 citations

Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumour cells

1992 • 37 citations

COLLABORATIVE TRANSFORMATION WITH TWO ONCOGENES; myc COLLABORATING WITH V-src IN PRIMARY CELLS AND WITH AN IMMORTALIZATION-POSITIVE SV40 MUTATED ONCOGENE IN ESTABLISHED RAT CELLS

1989 • 2 citations