Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors

Cloned Glutamate Receptors

1994 • 3,989 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

Protein modules and signalling networks

1995 • 2,447 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

1996 • 1,047 citations

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

1999 • 1,024 citations

Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

1999 • 980 citations

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

2002 • 964 citations

Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

1997 • 962 citations

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 921 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities.

1980 • 780 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Cell-penetrating peptides

2000 • 767 citations

Binding of Neuroligins to PSD-95

1997 • 731 citations

Postsynaptic Signaling and Plasticity Mechanisms

2002 • 713 citations

PDZ Domains: Structural Modules for Protein Complex Assembly

2002 • 696 citations

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

2002 • 693 citations

Structure and function of the NMDA receptor channel

1995 • 645 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

1997 • 614 citations

Competitive binding of α-actinin and calmodulin to the NMDA receptor

1997 • 591 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors

1998 • 557 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1

1999 • 540 citations

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

1997 • 538 citations

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

1998 • 538 citations

Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death

2001 • 532 citations

Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.

1989 • 484 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

The postsynaptic density at glutamatergic synapses

1997 • 474 citations

Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo

1998 • 465 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization

1994 • 420 citations

Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

1995 • 411 citations

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

1998 • 396 citations

Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine

1970 • 388 citations

Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP

2001 • 383 citations

TAT-Mediated Protein Transduction into Mammalian Cells

2001 • 381 citations

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

1999 • 371 citations

The structure and function of glutamate receptor ion channels

2002 • 366 citations

Interaction of ion channels and receptors with PDZ domain proteins

1997 • 362 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP

1998 • 354 citations

Dual‐component amino‐acid‐mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.

1985 • 334 citations

Molecular organization of the postsynaptic specialization

2001 • 330 citations

Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

1996 • 327 citations

PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

2001 • 322 citations

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.

1994 • 314 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

CRIPT, a Novel Postsynaptic Protein that Binds to the Third PDZ Domain of PSD-95/SAP90

1998 • 304 citations

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.

1995 • 297 citations

Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor

2000 • 295 citations

Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca²⁺Influx in Hippocampal CA1 Neurons of Gerbil

1997 • 295 citations

High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus

1995 • 292 citations

Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor

1995 • 290 citations

Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density

2001 • 290 citations

Messenger proteins: homeoproteins, TAT and others

2000 • 274 citations

Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity

1998 • 270 citations

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

1991 • 265 citations

Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice

1982 • 261 citations

PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

1997 • 250 citations

Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules

2000 • 243 citations

Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity

2000 • 238 citations

Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain

1999 • 206 citations

Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis

1999 • 194 citations

Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus

1999 • 186 citations

Signal transduction molecules at the glutamatergic postsynaptic membrane1Published on the World Wide Web on 24 October 1997.1

1998 • 184 citations

Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins.

1978 • 183 citations

Differences in membrane structure between excitatory and inhibitory synapses in the cerebellar cortex

1974 • 157 citations

GRASP-1

2000 • 153 citations

Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neurons

1994 • 141 citations

The postsynaptic density

1993 • 136 citations

An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90

2000 • 124 citations

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

1995 • 118 citations

Small molecule antagonists of proteins

2002 • 116 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95

1999 • 109 citations

NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines

1997 • 107 citations

Regulation of Signal Transduction by Protein Targeting: The Case for CaMKII

2001 • 105 citations

Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.

1994 • 97 citations

White Matter Injury in Spinal Cord Ischemia

2000 • 96 citations

Synapse structure: Glutamate receptors connected by the shanks

1999 • 91 citations

Interaction of the Tyrosine Kinase Pyk2 with the N-Methyl-d-aspartate Receptor Complex via the Src Homology 3 Domains of PSD-95 and SAP102

2003 • 81 citations

Cytosolic calcium concentrations and cell death in vitro.

1996 • 74 citations

The GluR2 hypothesis: Ca(++)-permeable AMPA receptors in delayed neurodegeneration.

1996 • 74 citations

Untitled

1996 • 63 citations

[11] Nitric oxide signaling in the nervous system

1996 • 60 citations

N‐Cadherin Is a Major Glycoprotein Component of Isolated Rat Forebrain Postsynaptic Densities

1995 • 59 citations

Grey Matter and White Matter Ischemic Damage is Reduced by the Competitive AMPA Receptor Antagonist, SPD 502

2002 • 58 citations

Assessment of mitochondrial membrane potential as an indicator of cytotoxicity

1991 • 58 citations

The Influence of Glutamate Receptor 2 Expression on Excitotoxicity in GluR2 Null Mutant Mice

2001 • 56 citations

Glutamate Neurotoxicity, Calcium, and Zinc^a

1989 • 51 citations

AMPA Receptor Antagonists

2001 • 48 citations

Intracellular free calcium increases in cultured cortical neurons deprived of oxygen and glucose.

1990 • 48 citations

Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways.

2003 • 47 citations

Glutamate Receptor Trafficking in Synaptic Plasticity

2002 • 47 citations

Activation of mGluR5 Modulates GABA_AReceptor Function in Retinal Amacrine Cells

2002 • 46 citations

Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein Kinase A

1992 • 45 citations

Plasma Clearance, Tissue Distribution and Catabolism of Cationized Albumins with Increasing Isoelectric Points in the Rat

1984 • 43 citations

Hypoxic neuronal injury in tissue culture is associated with delayed calcium accumulation.

1990 • 41 citations

Plasticity: downstream of glutamate

2001 • 38 citations

Treatment with conotoxin, an ‘N-type’ calcium channel blocker, in neuronal hypoxic-ischemic injury

1990 • 37 citations

Inhibitors of AMPA and Kainate Receptors

2001 • 33 citations

[7] Identification of ion channel-associated proteins using the yeast two-hybrid system

1998 • 32 citations

Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody

2002 • 16 citations

Hypoxic Neurodegeneration in Culture: Calcium Influx, Electron Microscopy, and Neuroprotection with Excitatory Amino Acid Antagonists

1992 • 9 citations