Small molecule antagonists of proteins

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

1985 • 2,597 citations

Principles of protein-protein interactions.

1996 • 2,594 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

2001 • 1,035 citations

Interior and surface of monomeric proteins

1987 • 924 citations

The Depth of Chemical Time and the Power of Enzymes as Catalysts

2001 • 884 citations

INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

1998 • 717 citations

Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

1998 • 628 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Kinetics of protein-protein association explained by Brownian dynamics computer simulation.

1992 • 578 citations

Rapid, electrostatically assisted association of proteins

1996 • 562 citations

Energetics of protein-protein interactions: Analysis ofthe Barnase-Barstar interface by single mutations and double mutant cycles

1995 • 559 citations

Prediction of protein–protein interactions by docking methods

2002 • 453 citations

Binding in the growth hormone receptor complex.

1996 • 434 citations

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

2001 • 338 citations

Rational design of faster associating and tighter binding protein complexes.

2000 • 302 citations

Inhibition of Protein−Protein Association by Small Molecules: Approaches and Progress

2002 • 284 citations

Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering

1993 • 283 citations

The kinetics of protein-protein recognition

1997 • 205 citations

Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar 1 1Edited by B. Honig

1998 • 199 citations

Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B

1992 • 186 citations

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

2002 • 173 citations

Generation of an LFA-1 Antagonist by the Transfer of the ICAM-1 Immunoregulatory Epitope to a Small Molecule

2002 • 169 citations

Localization of the Vinblastine-binding Site on β-Tubulin

1996 • 158 citations

Seven-transmembrane receptors: crystals clarify

2002 • 158 citations

Principles of protein-protein recognition from structure to thermodynamics

1995 • 147 citations

Signaling pathways induced by vascular endothelial growth factor (review).

2000 • 119 citations

G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin.

2001 • 119 citations

Walking the Walk

2002 • 108 citations

Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling.

2002 • 87 citations

Comparison of protein–protein interactions in serine protease‐inhibitor and antibody‐antigen complexes: Implications for the protein docking problem

1999 • 85 citations

[13] Enzymatic transition-state analysis and transition-state analogs

1999 • 83 citations

The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II

2000 • 44 citations

Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*–π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists

2001 • 33 citations

Small molecule antagonists of the LFA-1/ICAM-1 interaction as potential therapeutic agents

2001 • 30 citations

Structure-Based Design of Novel Anticancer Agents

2001 • 25 citations

Inhibitors of protein-protein interactions

2002 • 21 citations

New inhibitors of tubulin polymerisation

1999 • 21 citations

Novel H3 receptor antagonists. Sulfonamide homologs of histamine

1998 • 17 citations

Protein Crystallography and Examples of its Applications in Medicinal Chemistry

1999 • 8 citations

Design and Discovery of Aspartyl Protease Inhibitors

1984 • 7 citations

Chapter 24. Pharmacokinetics and design of aspartyl protease inhibitors

2001 • 6 citations

New antiplatelet drugs

1997 • 3 citations

New antiplatelet drugs

1999 • 2 citations