Biologic agents for treating rheumatoid arthritis. Concepts and progress

American college of rheumatology preliminary definition of improvement in rheumatoid arthritis

1995 • 2,778 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis

1995 • 917 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Combination Therapy with Cyclosporine and Methotrexate in Severe Rheumatoid Arthritis

1995 • 530 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

2008 • 514 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.

1995 • 422 citations

Decrease in cellularity and expression of adhesion molecules by anti–tumor necrosis factor α monoclonal antibody treatment in patients with rheumatoid arthritis

1996 • 377 citations

Role of interleukin‐1, tumor necrosis factor α, and interleukin‐6 in cartilage proteoglycan metabolism and destruction effect of in situ blocking in murine antigen‐ and zymosan‐induced arthritis

1995 • 376 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

Maternal-Fetal Disparity in HLA Class II Alloantigens and the Pregnancy-Induced Amelioration of Rheumatoid Arthritis

1993 • 359 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial

1995 • 338 citations

Adhesion Molecules

1996 • 329 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Humanised monoclonal antibody therapy for rheumatoid arthritis

1992 • 316 citations

Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice.

1993 • 298 citations

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

1991 • 297 citations

Analysis of improvement in individual rheumatoid arthritis patients treated with disease‐modifying antirheumatic drugs, based on the findings in patients treated with placebo

1990 • 289 citations

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.

1993 • 288 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Adhesion Molecules — Blood Vessels and Blood Cells

1996 • 273 citations

Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1

1994 • 263 citations

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis

1996 • 255 citations

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1994 • 251 citations

Deactivation of vascular endothelium by monoclonal anti–tumor necrosis factor α antibody in rheumatoid arthritis

1996 • 239 citations

Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.

1994 • 238 citations

Apoptosis and functional fas antigen in rheumatoid arthritis synoviocytes

1995 • 234 citations

THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITIS

1995 • 234 citations

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor.

1992 • 229 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

Recombinant soluble tumor necrosis factor receptor (p80) fusion protein: toxicity and dose finding trial in refractory rheumatoid arthritis.

1996 • 219 citations

Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.

1987 • 211 citations

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.

1983 • 208 citations

The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in mice

1993 • 204 citations

Tetracyclines inhibit human synovial collagenase in vivo and in vitro.

1987 • 202 citations

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1995 • 194 citations

Reduction of synovial inflammation after anti‐cd4 monoclonal antibody treatment in early rheumatoid arthritis

1995 • 193 citations

Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.

1994 • 188 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

1993 • 186 citations

Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis.

1993 • 173 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Minocycline in active rheumatoid arthritis

1994 • 172 citations

In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short term cellular and molecular effects.

1996 • 168 citations

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.

1995 • 166 citations

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

1994 • 159 citations

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice

1988 • 158 citations

Possible role of V beta T cell receptor genes in susceptibility to collagen-induced arthritis in mice.

1988 • 151 citations

Oral type II collagen treatment in early rheumatoid arthritis. A double‐blind, placebo‐controlled, randomized trial

1996 • 147 citations

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.

1987 • 146 citations

Distal extremity swelling with pitting edema in polymyalgia rheumatica. Report of nineteen cases

1996 • 126 citations

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

1996 • 121 citations

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.

1996 • 121 citations

Use of a chimeric monoclonal anti‐CD4 antibody in patients with refractory rheumatoid arthritis

1993 • 120 citations

Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody

1994 • 118 citations

Double‐blind trial of recombinant γ‐interferon versus placebo in the treatment of rheumatoid arthritis

1989 • 110 citations

Heterogeneous effects of IFN-gamma in adjuvant arthritis.

1989 • 109 citations

Recombinant human interleukin‐1 receptor type I in the treatment of patients with active rheumatoid arthritis

1996 • 107 citations

Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

1995 • 107 citations

Campath‐1h, a humanized monoclonal antibody, in refractory rheumatoid arthritis

1995 • 103 citations

Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.

1995 • 100 citations

Type II collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera.

1985 • 91 citations

Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

1988 • 84 citations

In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.

1993 • 82 citations

Effects of administration of an anti‐cd5 plus immunoconjugate in rheumatoid arthritis. results of two phase ii studies

1993 • 79 citations

Amelioration of antigen‐induced arthritis in rabbits treated with monoclonal antibodies to leukocyte adhesion molecules

1992 • 76 citations

Chimeric cd4 monoclonal antibody cm‐t412 as a therapeutic approach to rheumatoid arthritis

1993 • 76 citations

Treatment of active refractory rheumatoid arthritis with humanized monoclonal antibody campath‐1h administered by daily subcutaneous injection

1995 • 67 citations

Percentage of anti‐CD4 monoclonal antibody‐coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens

1996 • 67 citations

Adherence of neutrophils induces release of soluble tumor necrosis factor receptor forms.

1994 • 64 citations

Interferon gamma in rheumatoid arthritis--a double blind study comparing human recombinant interferon gamma with placebo.

1988 • 63 citations

Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis.

1995 • 63 citations

Interleukin‐2 diphtheria fusion protein (dab₄₈₆il‐2) in refractory rheumatoid arthritis a double‐blind, placebo‐controlled trial with open‐label extension

1995 • 62 citations

Recombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo controlled study.

1992 • 61 citations

Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis

1985 • 60 citations

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.

1989 • 60 citations

Synovial tissue response to treatment with campath‐1h

1995 • 54 citations

A double‐blind, placebo‐controlled study of anti‐CD5 immunoconjugate in patients with rheumatoid arthritis

1996 • 53 citations

DAB₄₈₆IL‐2 fusion toxin in refractory rheumatoid arthritis

1993 • 51 citations

Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis

1994 • 50 citations

Chimeric CD7 monoclonal antibody therapy in rheumatoid arthritis.

1992 • 46 citations

Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice.

1996 • 43 citations

Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis.

1996 • 43 citations

V beta 17 T cell receptor peptide vaccination in rheumatoid arthritis: results of phase I dose escalation study.

1996 • 42 citations

Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

1989 • 42 citations

Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen.

1990 • 41 citations

Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis.

1995 • 38 citations

Effects of Inoculation with Attenuated Autologous T Cells in Patients with Rheumatoid Arthritis

1993 • 35 citations

Conserved Motifs in Rheumatoid Arthritis Synovial Tissue T-Cell Receptor β Chains

1993 • 30 citations

Do nonimmunologically mediated pathways play a role in the pathogenesis of rheumatoid arthritis?

1993 • 29 citations

LONG-TERM PROTECTION AGAINST THE EFFECTS OF TUMOUR NECROSIS FACTOR BY CONTROLLED DELIVERY OF THE SOLUBLE p55 TNF RECEPTOR

1996 • 24 citations

Identification of class ii HLA alloantibodies in placenta‐eluted gamma globulins used for treating rheumatoid arthritis

1987 • 23 citations

Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-?4 antibody in adjuvant arthritis

1995 • 21 citations

DO NONIMMUNOLOGICALLY MEDIATED PATHWAYS PLAY A ROLE IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS?

1993 • 20 citations

Induction of an Anti-Vaccine Response by T Cell Vaccination in Non-human Primates and Humans

1993 • 18 citations

Treatment of rheumatoid arthritis by immunization with mononuclear white blood cells: results of a preliminary trial.

1996 • 17 citations

Multicenter double-blind trial of interferon-gamma versus placebo in the treatment of rheumatoid arthritis.

1991 • 13 citations

N‐[4‐hydroxyphenyl] retinamide in rheumatoid arthritis: A pilot study

1996 • 13 citations

There is an age-related increase in corticosteroid secretion in rats. Could a similar increase with age predispose postmenopausal women to develop osteoporosis?

1991 • 4 citations