Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS

1989 • 1,137 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin

1972 • 420 citations

Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG

1979 • 411 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

TNFα—A PIVOTAL ROLE IN RHEUMATOID ARTHRITIS?

1992 • 377 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice.

1992 • 363 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α

1991 • 290 citations

Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.

1989 • 275 citations

Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.

1992 • 234 citations

DETECTION OF CYTOKINES AT THE CARTILAGE/PANNUS JUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: IMPLICATIONS FOR THE ROLE OF CYTOKINES IN CARTILAGE DESTRUCTION AND REPAIR

1992 • 233 citations

Stimulation of endothelial cell binding of lymphocytes by tumor necrosis factor.

1987 • 197 citations

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

1987 • 173 citations

In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.

1988 • 158 citations

Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta

1992 • 103 citations

Early appearance of activated CD4+ T lymphocytes and class II antigen-expressing cells in joints of DBA/1 mice immunized with type II collagen.

1988 • 93 citations

Anti‐T cell receptor antibody treatment of rats with established autologous collagen‐induced arthritis: suppression of arthritis without reduction of anti‐type II collagen autoantibody levels

1991 • 81 citations

Treatment of Rheumatoid Arthritis with Single Dose or Weekly Pulses of Chimaeric Anti‐CD4 Monoclonal Antibody

1992 • 73 citations

The progression of the inflammation in established collagen‐induced arthritis can be altered by treatments with immunological or pharmacological agents which inhibit T cell activities

1988 • 68 citations

Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvement of both DTH and immune complex mediated mechanisms.

1989 • 45 citations

Effects of tumor necrosis factor alpha (TNF-alpha) on collagen arthritis.

1992 • 42 citations

Activated Type II Collagen Reactive T Cells are not Eliminated by in vivo Anti-CD4 Treatment. Implications for Therapeutic Approaches on Autoimmune Arthritis

1992 • 20 citations

Intervention with immunomodulatory agents: monoclonal antibody therapy

1992 • 15 citations

New therapeutic approaches in rheumatoid arthritis.

1989 • 4 citations