ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

2002 • 1,019 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates

2006 • 622 citations

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

2006 • 514 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

2002 • 424 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2007 • 263 citations

Genetic Evidence Supporting Selection of the Vα14i NKT Cell Lineage from Double-Positive Thymocyte Precursors

2005 • 262 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2008 • 251 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer

2007 • 233 citations

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

2008 • 222 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

CD4-CD8 Lineage Commitment Is Regulated by a Silencer Element at the ThPOK Transcription-Factor Locus

2008 • 133 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis

2003 • 121 citations

Runx3 Regulates Integrin αE/CD103 and CD4 Expression during Development of CD4−/CD8+ T Cells

2005 • 112 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis

2003 • 101 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision

2004 • 95 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity

2005 • 64 citations

CD4-CD8 lineage commitment: an inside view

2005 • 54 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Visualization of CD4/CD8 T Cell Commitment

1998 • 41 citations

Differentiation of CD4^highCD8^low coreceptor‐skewed thymocytes into mature CD8 single‐positive cells independent of MHC class I recognition

1997 • 20 citations