Visualization of CD4/CD8 T Cell Commitment

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

Selective Events in T Cell Development

1994 • 486 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 • 384 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Activation events during thymic selection.

1992 • 326 citations

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.

1994 • 325 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex

1988 • 205 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.

1990 • 116 citations

An Enhancer That Directs Lineage-Specific Expression of CD8 in Positively Selected Thymocytes and Mature T Cells

1997 • 113 citations

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

1994 • 102 citations

The selection of the α,β heterodimeric T-cell receptor for antigen

1986 • 100 citations

Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos.

1990 • 97 citations

Lymphocyte populations and immune responses in CD5‐deficient mice

1994 • 96 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1992 • 93 citations

Preferential positive selection of V_α2⁺CD8⁺ T cells in mouse strains expressing both H‐2^k and T cell receptor V_α^a haplotypes: determination with a V_α2‐specific monoclonal antibody

1992 • 81 citations

Evidence for a single-niche model of positive selection.

1994 • 76 citations

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1997 • 75 citations

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice.

1994 • 59 citations

The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection

1996 • 56 citations

Stochastic component to development of class I major histocompatibility complex-specific T cells.

1994 • 54 citations

Lineage Commitment in the Thymus: Only the Most Differentiated (TCRhibcl-2hi) Subset of CD4+CD8+Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

1996 • 51 citations

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1997 • 51 citations

Role of coreceptors in positive selection and lineage commitment.

1994 • 49 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.

1995 • 46 citations

Two distinct pathways of positive selection for thymocytes

1998 • 45 citations

Positive selection induces CD4 promoter and enhancer function

1997 • 37 citations

Generation of mature T cell populations in the thymus: CD4 or CD8 down‐regulation occurs at different stages of thymocyte differentiation

1994 • 36 citations

A human CD4 transgene rescues CD4⁻CD8⁺ cells in β2‐microglobulin‐deficient mice

1994 • 35 citations

CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection

1996 • 26 citations

A Challenge to the Instructive Model of Positive Selection

1993 • 24 citations

Evidence for a selective and multi‐step model of T cell differentiation: CD4⁺CD8^low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

1994 • 23 citations

Thymocytes control the CD4 gene differently from mature T lymphocytes

1997 • 22 citations

Differentiation of CD4^highCD8^low coreceptor‐skewed thymocytes into mature CD8 single‐positive cells independent of MHC class I recognition

1997 • 20 citations

Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation

1997 • 15 citations