Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENT

1999 • 245 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8⁺memory T cells

2002 • 199 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

The CD8 Population in CD4-deficient Mice Is Heavily Contaminated with MHC Class II–restricted T Cells

2004 • 133 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

An Enhancer That Directs Lineage-Specific Expression of CD8 in Positively Selected Thymocytes and Mature T Cells

1997 • 113 citations

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo

2004 • 111 citations

Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals

1997 • 110 citations

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

2004 • 109 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision

2004 • 95 citations

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1992 • 93 citations

Automated identification of subpopulations in flow cytometric list mode data using cluster analysis

1985 • 79 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair

1993 • 69 citations

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

2001 • 67 citations

B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.

1997 • 66 citations

Hierarchical Interactions of Control Elements Determine CD8α Gene Expression in Subsets of Thymocytes and Peripheral T Cells

1998 • 66 citations

A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.

1997 • 63 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

Strength of Signaling by CD4 and CD8 Coreceptor Tails Determines the Number but Not the Lineage Direction of Positively Selected Thymocytes

2001 • 57 citations

Unraveling a Revealing Paradox

2003 • 56 citations

Highly Efficient Selection of CD4 and CD8 Lineage Thymocytes Supports an Instructive Model of Lineage Commitment

2000 • 36 citations

Functional and Molecular Analysis of the Double-Positive Stage-Specific CD8 Enhancer E8III during Thymocyte Development

2005 • 35 citations

Interaction of the T cell receptor with bacterial superantigens

1993 • 25 citations

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4

2005 • 22 citations

CD8 Coreceptor Extinction in Signaled CD4⁺CD8⁺ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

2000 • 21 citations