Differentiation of CD4^highCD8^low coreceptor‐skewed thymocytes into mature CD8 single‐positive cells independent of MHC class I recognition

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Positive Selection of Thymocytes

1995 • 604 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Selective Events in T Cell Development

1994 • 486 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Thymic selection: a matter of life and death

1992 • 184 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Phenotypic changes accompanying positive selection of CD4⁺CD8⁺ thymocytes

1992 • 64 citations

The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection

1996 • 56 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.

1995 • 46 citations

Small cortical thymocytes are subject to positive selection.

1994 • 38 citations

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection

1993 • 37 citations

Generation of mature T cell populations in the thymus: CD4 or CD8 down‐regulation occurs at different stages of thymocyte differentiation

1994 • 36 citations

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development.

1993 • 34 citations

Asynchronous Coreceptor Downregulation after Positive Thymic Selection: Prolonged Maintenance of the Double Positive State in CD8 Lineage Differentiation Due to Sustained Biosynthesis of the CD4 Coreceptor

1997 • 28 citations

Selective activation of CD8 T cell effector functions by epitope variants of lymphocytic choriomeningitis virus glycoprotein.

1996 • 27 citations

Evidence for a selective and multi‐step model of T cell differentiation: CD4⁺CD8^low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

1994 • 23 citations

A novel mouse thymocyte antigen (F3Ag): down-regulation during the CD4⁺CD8⁺ double-positive stage indicates positive selection

1996 • 14 citations