The transferrin receptor: role in health and disease

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

1983 • 1,757 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Siderophores: Structure and Function of Microbial Iron Transport Compounds

1995 • 1,585 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

1985 • 1,153 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 727 citations

Iron metabolism in man

1979 • 726 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Iron transport and storage

1987 • 688 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

RIBONUCLEOTIDE REDUCTASES

1998 • 657 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

1998 • 635 citations

Cell Biology of Heme

1999 • 571 citations

Transferrin receptor is necessary for development of erythrocytes and the nervous system

1999 • 555 citations

Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

1997 • 539 citations

Transferrin receptors in human tissues: their distribution and possible clinical relevance.

1983 • 527 citations

Function and regulation of transferrin and ferritin.

1998 • 518 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

1993 • 510 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

Biosynthesis of heme and chlorophylls

1990 • 465 citations

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

1983 • 448 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia.

1992 • 383 citations

Serum Transferrin Receptor

1993 • 378 citations

Iron metabolism in health and disease

1995 • 375 citations

Identification of a Hypoxia Response Element in the Transferrin Receptor Gene

1999 • 359 citations

TRANSFER OF IRON FROM SERUM IRON-BINDING PROTEIN TO HUMAN RETICULOCYTES*

1959 • 356 citations

Primary structure of human transferrin receptor deduced from the mRNA sequence

1984 • 351 citations

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1997 • 342 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA.

1989 • 334 citations

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

1998 • 297 citations

Iron metabolism in health and disease

1994 • 292 citations

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

1996 • 291 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome

1995 • 285 citations

Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9.

1982 • 275 citations

Changes in cell surface antigen expression during hemopoietic differentiation

1982 • 260 citations

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

1999 • 249 citations

Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation

1998 • 234 citations

Gene transfer, expression, and molecular cloning of the human transferrin receptor gene

1984 • 224 citations

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

1994 • 221 citations

Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.

1987 • 220 citations

Serum transferrin receptor is a truncated form of tissue receptor.

1990 • 215 citations

The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells

1999 • 214 citations

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

1995 • 209 citations

Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor.

1987 • 208 citations

Iron regulatory elements (IREs): a family of mRNA non-coding sequences

1994 • 207 citations

Gene regulation by Ets proteins

1993 • 199 citations

Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site.

1987 • 198 citations

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

1996 • 194 citations

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1987 • 192 citations

A new role for the transferrin receptor in the release of iron from transferrin

1991 • 186 citations

Mosquito transferrin, an acute-phase protein that is up-regulated upon infection

1997 • 183 citations

Transferrin receptor: Its biological significance

1985 • 172 citations

The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes

1984 • 170 citations

Transferrin receptors and iron uptake during erythroid cell development

1982 • 164 citations

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

1997 • 164 citations

Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis

1999 • 157 citations

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1986 • 151 citations

Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation

1989 • 147 citations

Oxidative Stress Induces Activation of a Cytosolic Protein Responsible for Control of Iron Uptake

1995 • 146 citations

Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis

1988 • 140 citations

Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism

1996 • 137 citations

Regulation of Protein Synthesis

1967 • 133 citations

Iron-Dependent Regulation of Ferritin and Transferrin Receptor Expression by the Iron-Responsive Element Binding Protein

1992 • 132 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Isolation and molecular cloning of transferrin from the tobacco hornworm, Manduca sexta. Sequence similarity to the vertebrate transferrins.

1990 • 130 citations

Activation of iron regulatory protein-1 by oxidative stress in vitro

1998 • 126 citations

Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH

1991 • 125 citations

Regulation of Cellular Iron Metabolism by Erythropoietin: Activation of Iron-Regulatory Protein and Upregulation of Transferrin Receptor Expression in Erythroid Cells

1997 • 125 citations

YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.

1993 • 121 citations

Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis.

1991 • 121 citations

Transferrin, the transferrin receptor, and the uptake of iron by cells.

1998 • 118 citations

The Transferrin Receptor: Its Diagnostic Value and its Potential as Therapeutic Target

1993 • 117 citations

Expression of transferrin receptor on murine hematopoietic progenitors

1984 • 112 citations

Transferrin in a cockroach: molecular cloning, characterization, and suppression by juvenile hormone.

1993 • 110 citations

A Structurally Novel Transferrin-like Protein Accumulates in the Plasma Membrane of the Unicellular Green Alga Dunaliella salina Grown in High Salinities

1997 • 109 citations

Iron Up-modulates the Expression of Transferrin Receptors during Monocyte-Macrophage Maturation

1989 • 105 citations

Regulation of Iron Metabolism: Translational Effects Mediated by Iron, Heme, and Cytokines

1995 • 105 citations

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells

1995 • 99 citations

Inducibility of Transferrin Receptors on Friend Erythroleukemic Cells

1977 • 96 citations

Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex.

1993 • 95 citations

A highly cytotoxic human transferrin-ricin A chain conjugate used to select receptor-modified cells.

1984 • 94 citations

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2

1999 • 93 citations

Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA

1993 • 93 citations

Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

1998 • 91 citations

Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis.

1985 • 91 citations

Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.

1988 • 91 citations

Loss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach

1983 • 90 citations

The transferrin receptor.

1993 • 90 citations

Physical characterization of the transferrin receptor in human placentae.

1981 • 86 citations

Iron Uptake by the Halotolerant Alga DunaliellaIs Mediated by a Plasma Membrane Transferrin

1998 • 85 citations

Diagnostic Utility of Serum Transferrin Receptors Measurement in Assessing Iron Status

2009 • 85 citations

TRANSFERRIN BINDS SPECIFICALLY TO PACHYTENE SPERMATOCYTES

1983 • 84 citations

Iron Is Hot: An Update on the Pathophysiology of Hemochromatosis

1998 • 84 citations

Gene Expression in Proliferating Human Erythroid Cells

1999 • 82 citations

Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells.

1986 • 82 citations

The role of the transferrin receptor in human B lymphocyte activation.

1984 • 81 citations

Regulation of transferrin receptor mRNA expression

1994 • 80 citations

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.

1986 • 76 citations

Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding

1987 • 75 citations

Expression of human transferrin receptor is controlled by a gene on chromosome 3: Assignment using species specificity of a monoclonal antibody

1982 • 71 citations

Iron Is Hot: An Update on the Pathophysiology of Hemochromatosis

1998 • 70 citations

A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.

1991 • 66 citations

COMPARATIVE NUTRITIONOF IRON AND COPPER

1997 • 63 citations

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line

1997 • 62 citations

A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

1999 • 61 citations

Transferrin receptor gene is hyperexpressed and transcriptionally regulated in differentiating erythroid cells.

1992 • 61 citations

12 Regulation of Protein Synthesis

1987 • 60 citations

Human transferrin receptor: expression of the receptor is assigned to chromosome 3.

1982 • 59 citations

Iron transport and storage

1976 • 59 citations

Origin of a soluble truncated transferrin receptor

1993 • 59 citations

Rab15 Mediates an Early Endocytic Event in Chinese Hamster Ovary Cells

1999 • 59 citations

Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system

1991 • 58 citations

Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma

1984 • 58 citations

Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy

1998 • 58 citations

Oxidative Stress Leads to a Rapid Alteration of Transferrin Receptor Intravesicular Trafficking

1998 • 57 citations

Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages

1991 • 57 citations

Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor

1994 • 56 citations

Inhibition of proliferation and differentiation during early T cell development by anti‐transferrin receptor antibody

1994 • 55 citations

Transcriptional Inactivation of c-myc and the Transferrin Receptor in Dibutyryl Cyclic AMP-Treated HL-60 Cells

1987 • 54 citations

Identification of the O-linked glycosylation site of the human transferrin receptor

1992 • 54 citations

Reticulocyte membrane transferrin receptors

1980 • 52 citations

Acquired Iron-Deficiency Anemia Caused by an Antibody against the Transferrin Receptor

1984 • 51 citations

Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.

1990 • 51 citations

Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor

1994 • 50 citations

Control of heme synthesis during Friend cell differentiation: Role of iron and transferrin

1986 • 49 citations

Hemin regulates the expression of transferrin receptors in human hematopoietic cell lines

1982 • 48 citations

A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen.

1994 • 46 citations

Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia

1999 • 45 citations

A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis

1990 • 43 citations

Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells

1992 • 43 citations

Iron-Transferrin Requirements and Transferrin Receptor Expression in Proliferating Cells

2024 • 41 citations

A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line.

1986 • 39 citations

Post‐transcriptional regulation of the transferrin receptor and 4F2 antigen heavy chain mRNA during growth activation of spleen cells

1991 • 39 citations

Deletional analysis of the promoter region of the human transferrin receptor gene

1988 • 39 citations

Expression of transferrin receptors on mitogen-stimulated human peripheral blood lymphocytes: relation to cellular activation and related metabolic events.

1981 • 38 citations

Functional Analysis of Human/Chicken Transferrin Receptor Chimeras Indicates that the Carboxy‐Terminal Region is Important for Ligand Binding

1996 • 38 citations

The TANH-equation modified for the hemoglobin, oxygen, and carbon monoxide equilibrium

1993 • 37 citations

A Mitogen-Responsive Promoter Region That Is Synergistically Activated through Multiple Signalling Pathways

1993 • 37 citations

Cockroach transferrin closely resembles vertebrate transferrins in its metal ion-binding properties: A spectroscopic study

1996 • 37 citations

Molecular characteristics of the transferrin‐receptor complex of the rabbit reticulocyte

1978 • 35 citations

Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor.

1985 • 35 citations

Cleavage of the transferrin receptor by human granulocytes: Preferential proteolysis of the exosome-bound TFR

1996 • 32 citations

Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator

1987 • 32 citations

Identification of the transferrin receptor of the rabbit reticulocyte

1978 • 32 citations

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.

1987 • 31 citations

Complex Regulation of Transferrin Receptors during Erythropoietin‐Induced Differentiation of J2E Erythroid Cells

1997 • 30 citations

Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells

1991 • 27 citations

Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor

1990 • 27 citations

Effects of Nitrogen Monoxide on Cellular Iron Metabolism

1996 • 25 citations

Transferrin receptor synthesis is an early event in B cell activation.

1989 • 24 citations

A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways.

1993 • 20 citations

Exon/intron structure of the human transferrin receptor gene

1997 • 20 citations

SV40 activates transcription from the transferrin receptor promoter by inducing a factor which binds to the CRE/AP-1 recgonition sequence

1991 • 20 citations

Expression and loss of the transferrin receptor in growing and differentiating HD3 cells

1993 • 19 citations

Iterative endocytosis of transferrin by K562 cells

1994 • 16 citations

Biosynthesis of the transferrin receptor in rabbit reticulocytes.

1985 • 16 citations

Transcriptional regulation of transferrin receptor expression by cultured lymphoblastoid T cells treated with phorbol diesters.

1989 • 15 citations

Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells

1992 • 15 citations

Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro

1992 • 15 citations

Mitogen induction of nuclear factors that interact with a delayed responsive region of the transferrin receptor gene promoter.

1995 • 14 citations

Transcriptional Regulation of Transferrin Receptor Expression During Phorbol‐Ester‐Induced HL‐60 Cell Differentiation

1996 • 13 citations

Specific membrane receptors for diferric-transferrin in cultured rat skeletal myocytes and chick-embryo cardiac myocytes

1981 • 12 citations

Two Distinct Kinds of Tubular Organelles Involved in the Rapid Recycling and Slow Processing of Endocytosed Transferrin

1998 • 12 citations

A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

1999 • 11 citations

Friend erythroleukemia cell membrane transferrin receptors

1980 • 11 citations

New DNA Polymorphisms Define Ethnically Distinct Haplotypes in the Human Transferrin Receptor Gene

1998 • 10 citations

Phosphatidylinositol 3-kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1.

1997 • 8 citations

Iron Metabolism in Man

1980 • 5 citations

Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation

1994 • 5 citations

Gene transcription during in vitro activation of human B lymphocytes with Staphylococcus aureus Cowan I strain.

1990 • 4 citations

Haemoglobin Synthesis in Erythropoietin‐Stimulated J2E Cells Does not Require Increased Numbers of Transferrin Receptors

1997 • 1 citations

Deleted Work

1955 • 0 citations