Iron-Dependent Regulation of Ferritin and Transferrin Receptor Expression by the Iron-Responsive Element Binding Protein

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

1981 • 3,596 citations

The scanning model for translation: an update.

1989 • 3,525 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

1986 • 684 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.

1991 • 374 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

Regulation of Synthesis and Turnover of Ferritin in Rat Liver

1966 • 329 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.

1989 • 244 citations

Gene transfer, expression, and molecular cloning of the human transferrin receptor gene

1984 • 224 citations

Engineering of protein bound iron‐sulfur clusters

1989 • 211 citations

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

1990 • 205 citations

The structure of aconitase

1989 • 183 citations

Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells.

1987 • 165 citations

Mobilization of iron from endocytic vesicles. The effects of acidification and reduction.

1990 • 164 citations

Regulation of Interaction of the Iron-Responsive Element Binding Protein with Iron-Responsive RNA Elements

1989 • 164 citations

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

1986 • 164 citations

Proteins of Iron Storage and Transport

1990 • 155 citations

Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells.

1984 • 145 citations

Effect of iron chelators on the transferrin receptor in K562 cells.

1984 • 134 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.

1990 • 123 citations

Heme regulation of HeLa cell transferrin receptor number.

1984 • 116 citations

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation

1990 • 114 citations

Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.

1985 • 113 citations

Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA.

1990 • 112 citations

Translational repression in eukaryotes: partial purification and characterization of a repressor of ferritin mRNA translation.

1988 • 109 citations

Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse

1989 • 99 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

1988 • 87 citations

The importance of the 3'-untranslated region in the translational control of ferritin mRNA.

1988 • 84 citations

Requirements for the Translational Repression of Ferritin Transcripts in Wheat Germ Extracts by a 90-kDa Protein from Rabbit Liver

1989 • 80 citations

Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions.

1986 • 68 citations

Iron regulation of ferritin gene expression

1990 • 58 citations

Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites

1989 • 51 citations

An overview of iron metabolism at a molecular level

1989 • 46 citations

Chicken transferrin receptor gene: conservation 3′ noncoding sequences and expression in erythroid cells

1989 • 31 citations

Regulation of 5-aminolevulinate synthase in mouse erythroleukemic cells is different from that in liver.

1988 • 30 citations

The effect of iron administration on the incorporation of [14C]leucine into ferritin by rat-liver systems

1965 • 27 citations

Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload

1989 • 24 citations

Mapping <i>AK<sub>1</sub> ACO</i><i>N</i><sub>s</sub>, and <i>AK</i><sub>3</sub> to chromosome 9 in man employing an X/9 translocation and somatic cell hybrids

1977 • 23 citations

Murine ferritin heavy chain: isolation and characterization of a functional gene

1990 • 22 citations