Regulation of Iron Metabolism: Translational Effects Mediated by Iron, Heme, and Cytokines

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

Novel mechanism for translational control in regulation of ferritin synthesis by iron.

1976 • 324 citations

Induction of Ferritin Synthesis by Oxidative Stress

1995 • 321 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

The molecular action of tumor necrosis factor-alpha

1991 • 279 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels.

1988 • 214 citations

Iron-independent induction of ferritin H chain by tumor necrosis factor.

1991 • 211 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

Proteins of Iron Storage and Transport

1990 • 155 citations

Interleukin 1 induces ferritin heavy chain in human muscle cells

1990 • 135 citations

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

1992 • 133 citations

The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft.

1994 • 122 citations

Coordmation of cellular iron metabolism by post-transcriptional gene regulation

1992 • 121 citations

Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA.

1990 • 112 citations

A double life: cytosolic aconitase as a regulatory RNA binding protein.

1993 • 108 citations

The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control

1993 • 103 citations

Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse

1989 • 99 citations

Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions.

1991 • 95 citations

Unification of the ferritin family of proteins.

1992 • 94 citations

Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA

1993 • 93 citations

Mutagenesis of the iron-regulatory element further defines a role for RNA secondary structure in the regulation of ferritin and transferrin receptor expression.

1992 • 83 citations

Detection of oxidized and reduced glutathione with a recycling postcolumn reaction

1985 • 81 citations

Requirements for the Translational Repression of Ferritin Transcripts in Wheat Germ Extracts by a 90-kDa Protein from Rabbit Liver

1989 • 80 citations

Regulation of transferrin receptor mRNA expression

1994 • 80 citations

In vivo and in vitro modulation of the mRNA‐binding activity of iron‐regulatory factor

1992 • 77 citations

Transferrin receptor gene expression during rat liver regeneration. Evidence for post-transcriptional regulation by iron regulatory factorB, a second iron-responsive element-binding protein.

1994 • 76 citations

Binding of cytosolic aconitase to the iron responsive element of porcine mitochondrial aconitase mRNA

1992 • 74 citations

Structure of the 5' untranslated regulatory region of ferritin mRNA studied in solution

1990 • 67 citations

Cloning of a functional cDNA for the rabbit ferritin mRNA repressor protein. Demonstration of a tissue-specific pattern of expression.

1992 • 56 citations

Alternate iron transport pathway. Mobilferrin and integrin in K562 cells.

1994 • 55 citations

Enhanced Degradation of the Ferritin Repressor Protein During Induction of Ferritin Messenger RNA Translation

1992 • 52 citations

The inhibition of the iron responsive element RNA-protein interaction by heme does not mimic in vivo iron regulation.

1990 • 42 citations

Overexpression of Iron-Responsive Element-Binding Protein and Its Analytical Characterization as the RNA-Binding Form, Devoid of an Iron-Sulfur Cluster

1994 • 42 citations

Sequence and expression of the murine iron-responsive element binding protein

1991 • 39 citations

Localization of an RNA binding element of the iron responsive element binding protein within a proteolytic fragment containing iron coordination ligands

1994 • 33 citations

Cytosol intermediates in the transport of iron

1980 • 33 citations

Clinically-Silent Mutation in the Putative Iron-Responsive Element in Exon 17 of the β-Amyloid Precursor Protein Gene

1992 • 30 citations

Characteristics of the interaction of the ferritin repressor protein with the iron-responsive element

1991 • 25 citations

The increased susceptibility to hydrogen peroxide of the (post-)ischemic rat heart is associated with the magnitude of the low molecular weight iron pool

1994 • 23 citations

Irreversible steps in the ferritin synthesis induction pathway.

1994 • 20 citations

Decay of Superoxide catalyzed by ferritin

1993 • 12 citations