A Mitogen-Responsive Promoter Region That Is Synergistically Activated through Multiple Signalling Pathways

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

High efficiency gene transfer into mammalian cells

1984 • 498 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1979 • 366 citations

Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins

1985 • 331 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells.

1983 • 147 citations

An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein.

1982 • 143 citations

Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis.

1987 • 131 citations

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

1985 • 125 citations

A transcription factor active on the epidermal growth factor receptor gene.

1988 • 102 citations

Quick-Blot: Selective mRNA or DNA Immobilization from Whole Cells

1983 • 97 citations

A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter.

1991 • 85 citations

Transcription factor LSF binds two variant bipartite sites within the SV40 late promoter.

1990 • 82 citations

Identification, purification, and characterization of phosphotyrosine-specific protein phosphatases from cultured chicken embryo fibroblasts.

1984 • 77 citations

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.

1986 • 76 citations

Regulation of transferrin receptor expression in concanavalin a stimulated and gross virus transformed rat lymphoblasts

1982 • 56 citations

Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor.

1987 • 47 citations

Deletional analysis of the promoter region of the human transferrin receptor gene

1988 • 39 citations

Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter.

1990 • 36 citations

Dynamic interactions of c‐fos protein in serum‐stimulated 3T3 cells

1989 • 29 citations

Numerous proteins phosphorylated on tyrosine and enhanced tyrosine kinase activities in vanadate-treated NIH 3T3 fibroblasts

1988 • 25 citations

Vanadate inhibits degradation of short-lived, but not of long-lived, proteins in L-132 human cells

1989 • 13 citations

Analysis of cis-acting promoter elements using microinjected synthetic oligonucleotides

1990 • 5 citations

Interaction of multiple factors with a GC‐rich rlement within the mitogen responsive region of the human transferrin receptor gene

1992 • 4 citations