Effects of Nitrogen Monoxide on Cellular Iron Metabolism

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Efficient Trace-labelling of Proteins with Iodine

1958 • 2,571 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

Iron transport and storage

1987 • 688 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

1981 • 497 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators

1991 • 478 citations

Biosynthesis of heme and chlorophylls

1990 • 465 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Low molecular weight intracellular iron transport compounds

1977 • 389 citations

Structure of human lactoferrin at 3.2-A resolution.

1987 • 375 citations

Why nitric oxide?

1992 • 350 citations

Iron in biochemistry and medicine.

1974 • 341 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

1992 • 324 citations

Transferrin, biochemistry, physiology and clinical significance

1981 • 310 citations

NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective

1995 • 301 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.

1993 • 287 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis

1995 • 237 citations

Haem‐Dependent Activation of Guanylate Cyclase and Cyclic GMP Formation by Endogenous Nitric Oxide: A Unique Transduction Mechanism for Transcellular Signaling

1990 • 230 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

Nitric oxide, a biological effector

1991 • 203 citations

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

1994 • 199 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

The uptake of iron and transferrin by the human malignant melanoma cell

1990 • 178 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

The potent vasodilating and guanylyl cyclase activating dinitrosyl‐iron(II) complex is stored in a protein‐bound form in vascular tissue and is released by thiols

1991 • 163 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism

1996 • 137 citations

Function of the [2Fe−2S] Cluster in Mammalian Ferrochelatase: A Possible Role as a Nitric Oxide Sensor

1996 • 135 citations

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

1992 • 133 citations

Endothelium‐derived relaxing factor is a nitrosyl iron complex with thiol ligands

1991 • 132 citations

Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate.

1992 • 121 citations

Identification of the EPR-Active Iron-Nitrosyl Complexes in Mammalian Ferritins

1994 • 117 citations

Metmyoglobin and methemoglobin as efficient traps for nitrosyl hydride (nitroxyl) in neutral aqueous solution

1985 • 116 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells

1995 • 99 citations

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase

1993 • 93 citations

Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets.

1994 • 90 citations

Resonance Raman Spectroscopy of Soluble Guanylyl Cyclase Reveals Displacement of Distal and Proximal Heme Ligands by NO

1994 • 89 citations

Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: The effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake

1994 • 86 citations

Iron transport and storage

1976 • 59 citations

The source of non-heme iron that binds nitric oxide in cultivated macrophages

1992 • 55 citations

Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction

1995 • 51 citations

The effects of 2-acetylaminofluorene and nitrite on free radicals and carcinogenesis in rat liver.

1970 • 46 citations

Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis

1992 • 32 citations

Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells

1995 • 31 citations

Kinetics of the reactions of trioxodinitrate and nitrite ions with cytochrome d in Escherichia coli

1991 • 28 citations

A comparative study of chemically and enzymatically radioiodinated transferrin

1976 • 23 citations

Further study on the properties of the rat liver protein involved in a paramagnetic complex in the livers of carcinogen-treated rats

1972 • 23 citations

Nitric Oxide Interaction with Lactoferrin and its Production by Macrophage Cells Studied by EPR and Spin Trapping

1993 • 16 citations

Effect of the Synthetic Œstrogen Stilbœstrol on Pregnancy in the Rabbit

1958 • 6 citations