Molecular Genetics of Alzheimer's Disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

The prevalence of dementia: A quantitative integration of the literature

1987 • 1,300 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

1991 • 762 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

1992 • 725 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

über eigenartige Krankheitsfälle des späteren Alters

1911 • 673 citations

Overview of depression and psychosis in Alzheimer's disease

1989 • 665 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

The affected-pedigree-member method of linkage analysis.

1988 • 493 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 • 420 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings

1991 • 383 citations

Clinically diagnosed Alzheimer's disease: Autopsy results in 150 cases

1988 • 356 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Human apolipoprotein E isoprotein subclasses are genetically determined.

1981 • 341 citations

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1993 • 334 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

1991 • 311 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

1987 • 307 citations

Platelet Coagulation Factor XI _a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein

1990 • 299 citations

PRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM

1969 • 292 citations

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

1979 • 279 citations

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

1987 • 275 citations

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

1989 • 271 citations

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene

1987 • 271 citations

A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

1992 • 267 citations

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.

1992 • 265 citations

Apolipoprotein E: risk factor for Alzheimer disease.

1994 • 253 citations

Genomic organization of the human amyloid beta-protein precursor gene

1990 • 248 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Survival in Alzheimer's disease and vascular dementias

1985 • 227 citations

A Novel mRNA of the A4 Amyloid Precursor Gene Coding for a Possibly Secreted Protein

1989 • 209 citations

Familial aggregation in Alzheimer's disease

1988 • 195 citations

Epidemiology of dementia in a Finnish population

1982 • 193 citations

The Neuroanatomy of Alzheimer's Disease

1989 • 181 citations

Genetic linkage studies in Alzheimer's disease families

1988 • 163 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

Dementia of the Alzheimer type

1987 • 143 citations

A Population Study of Senile and Arteriosclerotic Psychoses

1969 • 139 citations

Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains

1992 • 138 citations

The 717Val→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

1991 • 131 citations

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease

1994 • 131 citations

Risk Factors for Alzheimer's Disease: Overview of the EURODEM Collaborative Re-Analysis of Case-Control Studies

1991 • 125 citations

Genetic linkage map of human chromosome 21

1988 • 125 citations

Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β‐amyloid precursor protein gene

1992 • 123 citations

The Genetics of Alzheimer's Disease

1977 • 116 citations

Risk of dementia in relatives of patients with Alzheimer's disease

1988 • 109 citations

Neurofibrillary degeneration and neuronal loss in alzheimer's disease

1989 • 106 citations

Genetic basis of lipoprotein disorders.

1989 • 90 citations

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 • 86 citations

ADULT ONSET HALLERVORDEN-SPATZ DISEASE WITH NEUROFIBRILLARY PATHOLOGY

1987 • 81 citations

Screening for the β-amyloid precursor protein mutation (APP717: Val → Ile) in extended pedigrees with early onset Alzheimer's disease

1991 • 80 citations

Mutation in codon 713 of the β amyloid precursor protein gene presenting with schizophrenia

1992 • 77 citations

An Alternative Secretase Cleavage Produces Soluble Alzheimer Amyloid Precursor Protein Containing a Potentially Amyloidogenic Sequence

1992 • 77 citations

Screening for mutations in the open reading frame and promoter of the β-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val→lle

1992 • 75 citations

A genetic linkage map of 17 markers on human chromosome 21

1989 • 74 citations

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

1992 • 70 citations

Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.

1991 • 69 citations

Linkage analysis of familial Alzheimer disease, using chromosome 21 markers.

1991 • 68 citations

Familial Alzheimer's disease: Progress and problems

1989 • 67 citations

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

1991 • 64 citations

Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.

1991 • 62 citations

The apolipoprotein E ε4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations

1994 • 59 citations

A Family-Genetic Study of Dementia of Alzheimer Type

1988 • 59 citations

The Amyloid Precursor-like Protein (APLP) Gene Maps to the Long Arm of Human Chromosome 19

1993 • 56 citations

Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14.

1983 • 52 citations

Sequencing of exons 16 and 17 of the β-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the β-amyloid sequence

1991 • 42 citations

Discordance and concordance of dementia of the Alzheimer type (DAT) in monozygotic twins indicate heritable and sporadic forms of Alzheimer's disease

1991 • 36 citations

Amyloidosis in aging and Alzheimer's disease.

1992 • 32 citations

Clinically-Silent Mutation in the Putative Iron-Responsive Element in Exon 17 of the β-Amyloid Precursor Protein Gene

1992 • 30 citations

A novel mutation in the ?-protein coding region of the amyloid ?-protein precursor (APP) gene

1992 • 27 citations

Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease

1989 • 25 citations

Demencia tipo Alzheimer con agregación familiar en Antioquia, Colombia

1994 • 21 citations

Descripción de una familia con demencia presenil tipo Alzheimer

1987 • 17 citations

Modelling the occurrence and pathology of Alzheimer's disease

1989 • 8 citations

Nucleic Acid Database Management

1987 • 7 citations

Locus Heterogeneity of Alzheimer’s Disease

1992 • 7 citations

D21S194, a jump clone from D21S16

1990 • 6 citations

Molecular Genetic Evidence for Etiologic Heterogeneity of Alzheimer’s Disease

1992 • 5 citations

NGF and Alzheimer's disease—Considerations and caveats

1989 • 1 citations

Deleted Work

1955 • 0 citations