Familial Alzheimer's disease: Progress and problems

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Nonparametric Estimation from Incomplete Observations

1958 • 7,673 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Analysis of Human Genetic Linkage.

1992 • 1,770 citations

Variable Number of Tandem Repeat (VNTR) Markers for Human Gene Mapping

1987 • 1,683 citations

The Genetics of Human Populations.

1972 • 1,645 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

The Genetics of Human Populations

1972 • 1,252 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

The genetics of human populations

1974 • 764 citations

Analysis of Human Genetic Linkage.

1987 • 709 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

Geographical relation between Alzheimer's disease and aluminum in drinking water.

1989 • 600 citations

Dementia of the Alzheimer Type

1980 • 518 citations

GEOGRAPHICAL RELATION BETWEEN ALZHEIMER'S DISEASE AND ALUMINIUM IN DRINKING WATER

1989 • 505 citations

The affected-pedigree-member method of linkage analysis.

1988 • 493 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Alzheimer's Neurofibrillary Changes

1962 • 396 citations

Risk factors for clinically diagnosed Alzheimer's disease

1986 • 365 citations

Analysis of human genetic linkage

1986 • 325 citations

Head injury as a risk factor for Alzheimer's disease

1985 • 300 citations

Epidemiology of clinically diagnosed Alzheimer's disease

1986 • 285 citations

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

1989 • 271 citations

Alzheimer's disease: Genetic aspects and associated clinical disorders

1983 • 269 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Familial Alzheimer Dementia: a prevalent disorder with specific clinical features

1984 • 242 citations

Aluminum and alzheimer's disease

1986 • 235 citations

Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer.

1987 • 222 citations

St. Mary's Hospital

1859 • 217 citations

Huntington's chorea.

1967 • 211 citations

Familial aggregation in Alzheimer's disease

1988 • 195 citations

Risk factors for Alzheimer's disease

1987 • 185 citations

A Family With Histologically Confirmed Alzheimer's Disease

1983 • 176 citations

Phenotypic heterogeneity in familial alzheimer's disease: A study of 24 kindreds

1989 • 171 citations

Evidence for and against the transmissibility of Alzheimer disease

1980 • 166 citations

Genetic linkage studies in Alzheimer's disease families

1988 • 163 citations

Senile Dementia. A Clinical, Sociomedical and Genetic Study.

1964 • 161 citations

Familial Alzheimer's disease

1963 • 156 citations

Alzheimer's Disease

1987 • 156 citations

Assessment of genetic risk for alzheimer's disease among first‐degree relatives

1989 • 147 citations

Familial alzheimer's disease in american descendants of the volga germans: Probable genetic founder effect

1988 • 145 citations

Dementia of the Alzheimer type

1987 • 143 citations

ALUMINIUM, CHEMICAL PHYSIOLOGY, AND ALZHEIMER'S DISEASE

1988 • 142 citations

Refused abortion. A follow-up study of 249 women whose applications were refused by the National Board of Health in Sweden.

1963 • 138 citations

Case‐control study of late onset “probable Alzheimer's disease”

1987 • 130 citations

Phenol emulsion-enhanced DNA-driven subtractive cDNA cloning: isolation of low-abundance monkey cortex-specific mRNAs.

1988 • 126 citations

DNA POLYMORPHISM AND HUMAN DISEASE

1986 • 121 citations

Studies in aging of the brain

1979 • 120 citations

The Genetics of Alzheimer's Disease

1977 • 116 citations

Risk of dementia in relatives of patients with Alzheimer's disease

1988 • 109 citations

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin

1981 • 103 citations

A Study of Familial Factors in Alzheimer's Disease

1982 • 101 citations

Organic Brain Syndrome and Aging

1980 • 87 citations

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 • 86 citations

AN UNUSUAL TYPE OF PRE-SENILE DEMENTIA (ATYPICAL ALZHEIMER'S DISEASE WITH AMYLOID VASCULAR CHANGE)

1954 • 85 citations

FAMILIAL ORGANIC PSYCHOSIS (ALZHEIMER'S TYPE)

1934 • 77 citations

THE USE OF LIFE TABLES AND SURVIVAL ANALYSIS IN TESTING GENETIC HYPOTHESES, WITH AN APPLICATION TO ALZHEIMER'S DISEASE1

1983 • 77 citations

Splitting schizophrenia

1988 • 76 citations

Twins With Alzheimer's Disease

1981 • 67 citations

The inheritance of alzheimer's disease: A new interpretation

1988 • 65 citations

[Alzheimer's presenile dementia transmitted in an extended kindred].

1985 • 63 citations

The genetics of alzheimer's disease: A review and a discussion of the implications

1986 • 60 citations

Alzheimer's Disease

1966 • 60 citations

Über präsenile Verblödungen

1932 • 60 citations

Kolloidchemische Betrachtungsweise seniler und präseniler Gewebsveränderungen

1932 • 58 citations

Transmission studies from blood of Alzheimer disease patients and healthy relatives.

1988 • 56 citations

Alzheimer's disease

1962 • 52 citations

INCIDENCE OF ALZHEIMER'S DISEASE IN A LARGE MENTAL HOSPITAL

1953 • 44 citations

AGE-DEPENDENT EXPRESSION OF FAMILIAL RISK IN ALZHEIMER'S DISEASE

1988 • 44 citations

Alzheimer's Disease, Down's Syndrome, and Aging: The Genetic Approach

1982 • 44 citations

Huntington's disease in monozygotic twins reared apart.

1983 • 42 citations

Sur les formes familiales précoces de la maladie d 'Alzheimer, pp. 249–274

1939 • 42 citations

�ber die famili�re juvenile Form der Alzheimerschen Krankheit mit neurologischen Herderscheinungen

1947 • 42 citations

Alzheimer's disease in one monozygotic twin

1972 • 42 citations

Distribution of biogenic amines and their catabolites in brains from patients with Alzheimer's disease

1987 • 39 citations

Familial aggregation in Alzheimer dementia—II. Clinical genetic implications of age-dependent onset

1986 • 39 citations

FAMILIAL PRESENILE DEMENTIA: REPORT OF CASE WITH CLINICAL AND PATHOLOGICAL FEATURES OF ALZHEIMER'S DISEASE

1939 • 30 citations

Alzheimer's disease in a mother and identical twin sons

1979 • 29 citations

Familial Alzheimer's Disease

1988 • 25 citations

Pedigree Study of Familial Alzheimer Disease

1984 • 25 citations

Nachweis von Erblichkeit bei der Alzheimer'schen Krankheit nebst Bemerkungen über den Altersvorgang im Gehirn

1939 • 24 citations

ALZHEIMER'S DISEASE

1934 • 24 citations

Sur les formes familiales précoces de la maladie d 'Alzheimer, pp. 275–301

1939 • 24 citations

FAMILIAL ALZHEIMER'S DISEASE

1959 • 24 citations

Zur Diagnostik der Alzheimerschen Krankheit

1929 • 23 citations

ALZHEIMER'S DISEASE

1931 • 21 citations

[The inheritance of senile psychoses].

1962 • 21 citations

A FAMILY WITH ALZHEIMER'S DISEASE

1946 • 20 citations

Discussion on the Mental and Physical Symptoms of the Presenile Dementias

1933 • 19 citations

Genealogische Erhebungen in einer Familie mit Alzheimerscher Krankheit

1961 • 19 citations

Ein Fall von juveniler heredit�rer Demenz vom Alzheimer Typ mit Parkinsonismus und Kl�ver-Bucy-Syndrom

1964 • 19 citations

Familial Alzheimer's disease presenting as levodopa-responsive parkinsonism.

1987 • 18 citations

Using survival methods to estimate age‐at‐onset distributions for genetic diseases with an application to Huntington disease

1989 • 16 citations

Presumed Alzheimer's Disease Beginning at Different Ages in Two Twins

1985 • 12 citations

New concepts in alzheimer's disease

1987 • 12 citations

Hanford's Radioactive Tumbleweed

1987 • 11 citations

Alzheimer’s disease

1942 • 11 citations

ALZHEIMER'S DISEASE IN SIBLINGS

1970 • 10 citations

A FAMILIAL ORGANIC PSYCHOSIS OF ALZHEIMER TYPE IN SIX KINSHIP OF THREE GENERATIONS

1963 • 9 citations

Zur Erblichkeit der Alzheimerschen Krankheit

1960 • 7 citations

Genetic Analysis of Late-Onset Diseases Using First-Degree Relatives

1988 • 6 citations

Alzheimer's disease in multiple members of a family.

1971 • 5 citations

Alzheimer's disease: New genetic research strategies

1986 • 4 citations

A clinico-pathologic report of Alzheimer's disease.

1956 • 4 citations

[A case of familial Alzheimer's disease].

1968 • 3 citations

[Pathogenic considerations on atrophic dementia; familial case of Alzheimer's disease].

1956 • 3 citations

DEMENTIAS IN SWEDISH TWINS

1988 • 3 citations

COSEGREGATION BETWEEN D21 SU ECORI ALLELES AND THE FAD (FAMILIAL ALZHEIMER??S DISEASE) GENE IN A PEDIGREE

1988 • 3 citations

DNA Markers in Familial Alzheimer’s Disease

1986 • 2 citations