Apolipoprotein E: risk factor for Alzheimer disease.

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers

1992 • 1,181 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Mild cognitive impairment in the elderly

1991 • 814 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

1989 • 532 citations

Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

1993 • 504 citations

The apolipoprotein ε4 allele in patients with Alzheimer's disease

1993 • 401 citations

Genotyping and sequence analysis of apolipoprotein E isoforms*1

1988 • 304 citations

Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

1993 • 262 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Prevalence of medically diagnosed dementia in a defined United States population

1989 • 137 citations

Apo E allele frequencies in younger (age 42–50) vs older (age 65–90) women

1993 • 114 citations

Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid

1991 • 88 citations

The molecular pathogenesis of Alzheimer's disease: clinical prospects

1992 • 29 citations