T-Cell Costimulatory Pathways in Allograft Rejection and Tolerance

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era

2004 • 1,258 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig

2003 • 1,060 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

2003 • 816 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

2000 • 646 citations

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

1999 • 607 citations

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

2004 • 595 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

2003 • 516 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

2001 • 459 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Immature, but not inactive: the tolerogenic function of immature dendritic cells

2002 • 389 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

2001 • 317 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.

1998 • 297 citations

Characterization of Mouse and Human B7-H3 Genes

2002 • 267 citations

Programmed Death-1 Targeting Can Promote Allograft Survival

2002 • 236 citations

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4⁺T cells

2002 • 221 citations

T‐cell costimulatory pathways in allograft rejection and tolerance

2003 • 218 citations

Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

1999 • 209 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival

1999 • 208 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

1998 • 185 citations

Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival

2005 • 181 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

The CD40 pathway in allograft rejection, acceptance, and tolerance

1997 • 180 citations

Role of the Programmed Death-1 Pathway in Regulation of Alloimmune Responses In Vivo

2005 • 177 citations

Induction, binding specificity and function of human ICOS

2000 • 175 citations

The Role of Novel T Cell Costimulatory Pathways in Autoimmunity and Transplantation

2002 • 165 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

Anti-CD40 therapy extends renal allograft survival in rhesus macaques1

2002 • 158 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1

2003 • 151 citations

Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients

2001 • 147 citations

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

1999 • 143 citations

Emerging paradigms of T-cell co-stimulation

2004 • 137 citations

INDUCTION THERAPY WITH MONOCLONAL ANTIBODIES SPECIFIC FOR CD80 AND CD86 DELAYS THE ONSET OF ACUTE RENAL ALLOGRAFT REJECTION IN NON-HUMAN PRIMATES1

2001 • 135 citations

Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates

2002 • 134 citations

CD27-Mediated Activation of Murine NK Cells

2000 • 133 citations

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity

2003 • 132 citations

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

2000 • 132 citations

Cutting Edge: Blockade of the CD28/B7 Costimulatory Pathway Inhibits Intestinal Allograft Rejection Mediated by CD4+ But Not CD8+ T Cells

1999 • 125 citations

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity

2003 • 117 citations

CD28-independent Costimulation of T Cells in Alloimmune Responses

2001 • 117 citations

DONOR ANTIGEN IS NECESSARY FOR THE PREVENTION OF CHRONIC REJECTION IN CTLA4IG-TREATED MURINE CARDIAC ALLOGRAFT RECIPIENTS1,2

1997 • 114 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

2001 • 98 citations

New Insights Into the Interactions Between T-Cell Costimulatory Blockade and Conventional Immunosuppressive Drugs

2002 • 97 citations

Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models

2001 • 95 citations

The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo

2003 • 91 citations

Blockade of the Interaction Between PD-1 and PD-L1 Accelerates Graft Arterial Disease in Cardiac Allografts

2004 • 89 citations

The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

1998 • 88 citations

Induction of immunologic tolerance to cardiac allograft by simultaneous blockade of inducible co-stimulator and cytotoxic T-lymphocyte antigen 4 pathway1

2003 • 79 citations

Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression

2003 • 77 citations

Role of 4-1BB in Allograft Rejection Mediated by CD8+ T Cells

2003 • 71 citations

Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Islet Allograft Survival

2004 • 68 citations

Finally, CTLA4Ig graduates to the clinic

1999 • 62 citations

The role of donor and recipient B7-1 (CD80) in allograft rejection.

1997 • 60 citations

CHRONIC BLOCKADE OF CD28-B7-MEDIATED T-CELL COSTIMULATION BY CTLA4Ig REDUCES INTIMAL THICKENING IN MHC CLASS I AND II INCOMPATIBLE MOUSE HEART ALLOGRAFTS1,2

1997 • 58 citations

ABSENCE OF HOST B7 EXPRESSION IS SUFFICIENT FOR LONG-TERM MURINE VASCULARIZED HEART ALLOGRAFT SURVIVAL

2000 • 54 citations

Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues

1995 • 49 citations

Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection

2004 • 41 citations

Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys1

2003 • 41 citations

Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody

1998 • 26 citations

CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy1

2003 • 25 citations

Mechanisms of Tolerance Induced by Donor-Specific Transfusion and ICOS-B7h Blockade in a Model of CD4+ T-Cell-Mediated Allograft Rejection

2005 • 25 citations

New monoclonal antibodies in renal transplantation.

2003 • 25 citations

Chronic rejection in experimental cardiac transplantation in a rat model

1994 • 25 citations

Physiologic regulation of alloimmune responses in vivo: the role of CTLA4 and TH1/TH2 cytokines

2001 • 7 citations