CD28-independent Costimulation of T Cells in Alloimmune Responses

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.

1997 • 268 citations

Structure and Dimerization of a Soluble Form of B7-1

2000 • 240 citations

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

1994 • 236 citations

The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival

1999 • 208 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

1998 • 185 citations

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28

1998 • 179 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

2000 • 135 citations

Tolerance in the mouse to major histocompatibility complex‐mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1992 • 128 citations

CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

1997 • 120 citations

LICOS, a primordial costimulatory ligand?

2000 • 109 citations

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

1996 • 105 citations

The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts.

1987 • 92 citations

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

2001 • 86 citations

ANALYSIS OF THE B7 COSTIMULATORY PATHWAY IN ALLOGRAFT REJECTION1

1997 • 84 citations

THE EFFECT OF ANTI-L3T4 MONOCLONAL ANTIBODY TREATMENT ON FIRST-SET REJECTION OF MURINE CARDIAC ALLOGRAFTS

1987 • 84 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

1995 • 78 citations

CD4-POSITIVE HELPER T LYMPHOCYTES MEDIATE MOUSE CARDIAC ALLOGRAFT REJECTION INDEPENDENT OF DONOR ALLOANTIGEN SPECIFIC CYTOTOXIC T LYMPHOCYTES

1993 • 75 citations

CD28-independent induction of experimental autoimmune encephalomyelitis

2001 • 75 citations

Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.

1996 • 74 citations

Type 2 Immune Deviation Has Differential Effects on Alloreactive CD4+ and CD8+ T Cells

1998 • 71 citations

Role of interleukin 12 and costimulators in T cell anergy in vivo

2009 • 71 citations

Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo

1997 • 70 citations

Expression of B7 Molecules in Recipient, Not Donor, Mice Determines the Survival of Cardiac Allografts

1999 • 67 citations

The role of donor and recipient B7-1 (CD80) in allograft rejection.

1997 • 60 citations

In Vivo use of monoclonal antibodies against murine T cell antigens

1989 • 56 citations

Acquired Thymic Tolerance: Role of CTLA4 in the Initiation and Maintenance of Tolerance in a Clinically Relevant Autoimmune Disease Model

1999 • 37 citations

PREVENTION OF ALLOANTIBODY FORMATION AFTER SKIN GRAFTING WITHOUT PROLONGATION OF GRAFT SURVIVAL

1988 • 35 citations

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.

1997 • 27 citations