Cutting Edge: Blockade of the CD28/B7 Costimulatory Pathway Inhibits Intestinal Allograft Rejection Mediated by CD4+ But Not CD8+ T Cells

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

CD4+ but not CD8+ cells are essential for allorejection.

1996 • 303 citations

ARE Th2 HELPER T LYMPHOCYTES BENEFICIAL, DELETERIOUS, OR IRRELEVANT IN PROMOTING ALLOGRAFT SURVIVAL?1

1997 • 170 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2

1994 • 109 citations

MANIPULATION OF CYTOKINE NETWORKS IN TRANSPLANTATION

1997 • 99 citations

CD4-POSITIVE HELPER T LYMPHOCYTES MEDIATE MOUSE CARDIAC ALLOGRAFT REJECTION INDEPENDENT OF DONOR ALLOANTIGEN SPECIFIC CYTOTOXIC T LYMPHOCYTES

1993 • 75 citations

The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo

1998 • 73 citations

CD28-B7 T CELL COSTIMULATORY BLOCKADE BY CTLA4Ig IN THE RAT RENAL ALLOGRAFT MODEL1,2

1996 • 73 citations

Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.

1997 • 51 citations

THE ROLE OF CD8 AND CD4 T CELLS IN INTESTINAL ALLOGRAFT REJECTION

1999 • 45 citations

INDUCTION OF TOLERANCE TO SMALL BOWEL ALLOGRAFTS IN HIGH-RESPONDER RATS BY COMBINING ANTI-CD4 WITH CTLA4Ig1

1996 • 33 citations

CTLA4IgG TREATMENT INDUCES LONG-TERM ACCEPTANCE OF RAT SMALL BOWEL ALLOGRAFTS1

1999 • 26 citations