CHRONIC BLOCKADE OF CD28-B7-MEDIATED T-CELL COSTIMULATION BY CTLA4Ig REDUCES INTIMAL THICKENING IN MHC CLASS I AND II INCOMPATIBLE MOUSE HEART ALLOGRAFTS1,2

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CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 378 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 340 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Immunologic basis of transplant-associated arteriosclerosis.

1996 • 214 citations

RAPAMYCIN INHIBITS ARTERIAL INTIMAL THICKENING CAUSED BY BOTH ALLOIMMUNE AND MECHANICAL INJURY

1993 • 204 citations

Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.

1996 • 179 citations

Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy.

1995 • 175 citations

CHRONIC VASCULAR REJECTION OF THE HEART AND THE KIDNEY—HAVE RATIONAL TREATMENT OPTIONS EMERGED?

1992 • 152 citations

Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations.

1994 • 149 citations

INCREASED EXPRESSION OF IL-4 AND IL-10 AND DECREASED EXPRESSION OF IL-2 AND INTERFERON-γ IN LONG-SURVIVING MOUSE HEART ALLOGRAFTS AFTER BRIEF CD4-MONOCLONAL ANTIBODY THERAPY1,2

1995 • 142 citations

UPREGULATION OF CYTOKINES ASSOCIATED WITH MACROPHAGE ACTIVATION IN THE LEWIS-TO-F344 RAT TRANSPLANTATION MODEL OF CHRONIC CARDIAC REJECTION1,2

1995 • 141 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

Effects of cyclosporin, FK506, and rapamycin on graft-vessel disease

1991 • 133 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

CTLA4Ig TREATMENT AMELIORATES THE LETHALITY OF MURINE GRAFT-VERSUS-HOST DISEASE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS

1994 • 123 citations

T cell costimulatory pathways

1995 • 73 citations

Sustained Anti-CD4/CD8 Treatment Blocks Inflammatory Activation and Intimal Thickening in Mouse Heart Allografts

1997 • 66 citations

EXPERIMENTAL GRAFT ARTERIOSCLEROSIS II. IMMUNOCYTOCHEMICAL ANALYSIS OF LESION DEVELOPMENT

1993 • 65 citations

Lymphocytic subsets and histopathologic changes associated with the development of heart transplant arteriosclerosis.

1992 • 57 citations

CORONARY ATHEROSCLEROSIS IN TRANSPLANTED MOUSE HEARTS

1995 • 51 citations

Experimental Graft Coronary Artery Disease in a Murine Heterotopic Cardiac Transplant Model

1995 • 29 citations