Modeling the MHC class I pathway by combining predictions of proteasomal cleavage,TAP transport and MHC class I binding

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

2016 • 18,941 citations

The use of the area under the ROC curve in the evaluation of machine learning algorithms

1997 • 6,352 citations

Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock

1999 • 2,805 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Antigen processing by the proteasome

2001 • 620 citations

2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care

2015 • 588 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

2002 • 518 citations

Hemodynamics of Mechanical Circulatory Support

2015 • 475 citations

Management of cardiogenic shock

2015 • 436 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products

2001 • 367 citations

The Current Use of Impella 2.5 in Acute Myocardial Infarction Complicated by Cardiogenic Shock: Results from the USpella Registry

2013 • 352 citations

Protein degradation and the generation of MHC class I-presented peptides

2002 • 340 citations

Identifying MHC Class I Epitopes by Predicting the TAP Transport Efficiency of Epitope Precursors

2003 • 324 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Prediction of proteasome cleavage motifs by neural networks

2002 • 286 citations

Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis

2001 • 268 citations

A Major Role for TPPII in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation

2004 • 263 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

2003 • 231 citations

Cannulation strategies for percutaneous extracorporeal membrane oxygenation in adults

2015 • 225 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance

2015 • 187 citations

PAProC: a prediction algorithm for proteasomal cleavages available on the WWW

2001 • 187 citations

The peptide-binding motif for the human transporter associated with antigen processing.

1995 • 186 citations

Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways

2002 • 180 citations

Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality

2016 • 173 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

An algorithm for the prediction of proteasomal cleavages

2000 • 154 citations

Pharmacological Criteria for Ventricular Assist Device Insertion Following Postcardiotomy Shock: Experience with the Abiomed BVS System

1999 • 151 citations

Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)

1997 • 133 citations

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber

1999 • 129 citations

Proteasome-Assisted Identification of a SSX-2-Derived Epitope Recognized by Tumor-Reactive CTL Infiltrating Metastatic Melanoma

2002 • 127 citations

Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

2000 • 121 citations

MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells

2000 • 117 citations

Extracorporeal life support in cardiovascular patients with observed refractory in-hospital cardiac arrest is associated with favourable short and long-term outcomes: A propensity-matched analysis

2015 • 116 citations

The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate

2000 • 116 citations

Mechanical Pre-Conditioning With Acute Circulatory Support Before Reperfusion Limits Infarct Size in Acute Myocardial Infarction

2015 • 115 citations

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28

2000 • 106 citations

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.

1996 • 103 citations

The Final N-Terminal Trimming of a Subaminoterminal Proline-Containing HLA Class I-Restricted Antigenic Peptide in the Cytosol Is Mediated by Two Peptidases

2002 • 91 citations

Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules.

1995 • 90 citations

Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells

1999 • 89 citations

A Kinetic Model of Vertebrate 20S Proteasome Accounting for the Generation of Major Proteolytic Fragments from Oligomeric Peptide Substrates

2000 • 79 citations

Altered Properties of the Branched Chain Amino Acid-preferring Activity Contribute to Increased Cleavages after Branched Chain Residues by the “Immunoproteasome”

1998 • 67 citations

Potential Candidates for a Structured Canadian ECPR Program for Out-of-Hospital Cardiac Arrest

2016 • 56 citations

Outcomes with Invasive vs Conservative Management of Cardiogenic Shock Complicating Acute Myocardial Infarction

2014 • 54 citations

Using the World Wide Web for predicting CTL epitopes

2003 • 50 citations

Assessment of Proteasomal Cleavage Probabilities from Kinetic Analysis of Time-dependent Product Formation

2002 • 49 citations

Simultaneous Prediction of Binding Capacity for Multiple Molecules of the HLA B44 Supertype

2003 • 45 citations

Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef

2003 • 42 citations

Proteasomes Get By with Lots of Help from Their Friends

2004 • 10 citations