Proteasomes Get By with Lots of Help from Their Friends

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

2002 • 486 citations

Making sense of mass destruction: quantitating MHC class I antigen presentation

2003 • 426 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Producing Nature’s Gene-Chips: The Generation of Peptides for Display by MHC Class I Molecules

2002 • 309 citations

Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

2003 • 298 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

A Major Role for TPPII in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation

2004 • 263 citations

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

2003 • 231 citations

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

2001 • 85 citations