Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

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Measuring inconsistency in meta-analyses

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Meta-analysis in clinical trials

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Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

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Operating Characteristics of a Rank Correlation Test for Publication Bias

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Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease

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Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis

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Principal components analysis corrects for stratification in genome-wide association studies

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Why Most Published Research Findings Are False

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‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

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The Combination of Estimates from Different Experiments

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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

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Assessing heterogeneity in meta-analysis: Q statistic or I² index?

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Beta blockade during and after myocardial infarction: An overview of the randomized trials

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Publication bias in clinical research

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Genome-wide association studies for common diseases and complex traits

2005 • 2,844 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

2007 • 2,820 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

2007 • 2,762 citations

How should meta‐regression analyses be undertaken and interpreted?

2002 • 2,618 citations

Genome-wide association study identifies novel breast cancer susceptibility loci

2007 • 2,342 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

2007 • 2,187 citations

Publication Bias in Meta‐Analysis

2005 • 2,063 citations

A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints

2005 • 2,033 citations

Association Mapping in Structured Populations

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The Hazards of Scoring the Quality of Clinical Trials for Meta-analysis

1999 • 1,977 citations

Comparison of Two Methods to Detect Publication Bias in Meta-analysis

2006 • 1,942 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

2006 • 1,815 citations

Methods for Meta-Analysis in Medical Research

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Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials

2004 • 1,728 citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

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A comprehensive review of genetic association studies

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The case of the misleading funnel plot

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Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods

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Replicating genotype–phenotype associations

2007 • 1,360 citations

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

2006 • 1,269 citations

Population stratification and spurious allelic association

2003 • 1,214 citations

Genotyping errors: causes, consequences and solutions

2005 • 1,177 citations

Uncertainty in heterogeneity estimates in meta-analyses

2007 • 1,119 citations

Gene–environment interactions in human diseases

2005 • 1,074 citations

5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review

2000 • 1,041 citations

Language bias in randomised controlled trials published in English and German

1997 • 1,002 citations

The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey

2007 • 939 citations

Factors Influencing Publication of Research Results

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Statistical Methods for Eliciting Probability Distributions

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Markov chain Monte Carlo method and its application

1998 • 787 citations

Meta-analysis of the literature or of individual patient data: is there a difference?

1993 • 752 citations

Detecting and describing heterogeneity in meta-analysis

1998 • 689 citations

Summing up evidence: one answer is not always enough

1998 • 671 citations

Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

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An exploratory test for an excess of significant findings

2007 • 632 citations

Effect of the Statistical Significance of Results on the Time to Completion and Publication of Randomized Efficacy Trials

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Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors

2005 • 605 citations

Invited Commentary: A Critical Look at Some Popular Meta-Analytic Methods

1994 • 516 citations

Genomic Control, a New Approach to Genetic-Based Association Studies

2001 • 512 citations

To IPD or not to IPD?

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How vague is vague? A simulation study of the impact of the use of vague prior distributions in MCMC using WinBUGS

2005 • 495 citations

A Bayesian Measure of the Probability of False Discovery in Genetic Epidemiology Studies

2007 • 487 citations

Why Most Published Research Findings Are False

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In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias

2005 • 473 citations

Relative Citation Impact of Various Study Designs in the Health Sciences

2005 • 465 citations

Population Stratification in Epidemiologic Studies of Common Genetic Variants and Cancer: Quantification of Bias

2000 • 445 citations

Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research

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Profiling early head and neck cancer

2005 • 438 citations

Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis

1996 • 421 citations

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

2005 • 394 citations

Meta-analysis of Genetic Studies in Ischemic Stroke

2004 • 385 citations

Misleading funnel plot for detection of bias in meta-analysis

2000 • 383 citations

Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations

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Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care

1995 • 349 citations

Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials

2005 • 329 citations

Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations

2007 • 328 citations

Random-Effects Meta-Analyses Are Not Always Conservative

1999 • 325 citations

New models of collaboration in genome-wide association studies: the Genetic Association Information Network

2007 • 317 citations

Design and Analysis of Admixture Mapping Studies

2004 • 310 citations

Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology

2003 • 309 citations

Glutathione S-Transferase Polymorphisms and Colorectal Cancer: A HuGE Review

2000 • 304 citations

Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data

2001 • 301 citations

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer

2004 • 293 citations

Accounting for Unmeasured Population Substructure in Case-Control Studies of Genetic Association Using a Novel Latent-Class Model

2001 • 253 citations

The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis

2006 • 251 citations

Non-Replication and Inconsistency in the Genome-Wide Association Setting

2007 • 245 citations

A road map for efficient and reliable human genome epidemiology

2006 • 241 citations

Selective Reporting Biases in Cancer Prognostic Factor Studies

2005 • 230 citations

Recent Developments in Genomewide Association Scans: A Workshop Summary and Review

2005 • 206 citations

Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

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Assessing publication bias in genetic association studies: evidence from a recent meta-analysis

2004 • 174 citations

Clinical Epidemiological Quality in Molecular Genetic Research

1999 • 172 citations

Dose-Related Association of MTHFR 677T Allele With Risk of Ischemic Stroke

2005 • 170 citations

Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature

2005 • 168 citations

The path from genome-based research to population health: Development of an international public health genomics network

2006 • 167 citations

CTLA-4 Gene Polymorphisms and Susceptibility to Type 1 Diabetes Mellitus: A HuGE Review and Meta-Analysis

2005 • 166 citations

Does Apolipoprotein E Genotype Influence the Risk of Ischemic Stroke, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage?

2005 • 163 citations

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

2005 • 163 citations

N-Acetyltransferase Polymorphisms and Colorectal Cancer: A HUGE Review

2000 • 152 citations

Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database

2006 • 130 citations

Commentary: Meta-analysis of Individual Participants' Data in Genetic Epidemiology

2002 • 118 citations

A Network of Investigator Networks in Human Genome Epidemiology

2005 • 117 citations

Selection in Reported Epidemiological Risks: An Empirical Assessment

2007 • 104 citations

Genetics of Ischaemic Stroke among Persons of Non-European Descent: A Meta-Analysis of Eight Genes Involving ∼ 32,500 Individuals

2007 • 104 citations

The Merits of Testing Hardy‐Weinberg Equilibrium in the Analysis of Unmatched Case‐Control Data: A Cautionary Note

2006 • 100 citations

Association of Collagen Iα 1 Sp1 Polymorphism with the Risk of Prevalent Fractures: A Meta-Analysis

2001 • 98 citations

Establishment of genetic associations for complex diseases is independent of early study findings

2004 • 94 citations

The Emergence of Networks in Human Genome Epidemiology

2006 • 92 citations

Meta-Analysis in Genome-Wide Association Datasets: Strategies and Application in Parkinson Disease

2007 • 82 citations

Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

2006 • 80 citations

Comparison of DNA- and RNA-Based Methods for Detection of TruncatingBRCA1 Mutations

2002 • 78 citations

Genetic Variation and Willingness to Participate in Epidemiologic Research: Data from Three Studies

2005 • 75 citations

Estimation of magnitude in gene–environment interactions in the presence of measurement error

2004 • 72 citations

Mendelian randomisation: a new spin or real progress?

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Commentary: Grading the credibility of molecular evidence for complex diseases

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Family-Based versus Unrelated Case-Control Designs for Genetic Associations

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Misclassification of genetic susceptibility biomarkers: implications for case-control studies and cross-population comparisons.

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Selection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies

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Genetic effects on HIV disease progression

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Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence

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An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment

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Data trawling: to fish or not to fish

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Joint effect of genes and environment distorted by selection biases: implications for hospital-based case-control studies.

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Flexible Design for Following Up Positive Findings

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Case‐Control Association Tests Correcting for Population Stratification

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The publication process itself was the major cause of publication bias in genetic epidemiology

2006 • 31 citations

Bayesian meta‐analysis and meta‐regression for gene–disease associations and deviations from Hardy–Weinberg equilibrium

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Molecular evidence‐based medicine

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Sources of evidence for systematic reviews of interventions in diabetes

2005 • 24 citations

Genetic variation and willingness to participate in epidemiologic research: Data from three studies

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Sample Bias Among Women With Retained DNA Samples for Future Genetic Studies

2006 • 17 citations

Bias in observational studies

2008 • 12 citations

Make it HuGE: human genome epidemiology reviews, population health, and the IJE

2006 • 9 citations