Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

Why Most Published Research Findings Are False

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Why Most Published Research Findings Are False

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Testing heterozygote excess and deficiency.

1995 • 801 citations

Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 gene

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The assessment of vertebral deformity: A method for use in population studies and clinical trials

1993 • 527 citations

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

2001 • 454 citations

Relation of Alleles of the Collagen Type Iα1 Gene to Bone Density and the Risk of Osteoporotic Fractures in Postmenopausal Women

1998 • 425 citations

Risk Factors for Increased Bone Loss in an Elderly Population The Rotterdam Study

1998 • 362 citations

Differential Genetic Effects of <EMPH TYPE="ITAL">ESR1</EMPH> Gene Polymorphisms on Osteoporosis Outcomes

2004 • 294 citations

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Molecular studies of identification of genes for osteoporosis: the 2002 update

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Mortality Associated with Vertebral Deformity in Men and Women: Results from the European Prospective Osteoporosis Study (EPOS)

1998 • 217 citations

Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture

2003 • 193 citations

Validity of Self-Report of Fractures: Results from a Prospective Study in Men and Women Across Europe

2000 • 183 citations

Clinical Epidemiological Quality in Molecular Genetic Research

1999 • 172 citations

Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature

2005 • 168 citations

The impact of genotyping error on family-based analysis of quantitative traits

2001 • 148 citations

Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study

2005 • 138 citations

Collagen type I 1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women

2003 • 117 citations

Two New Single-Nucleotide Polymorphisms in the COL1A1 Upstream Regulatory Region and Their Relationship to Bone Mineral Density

2002 • 104 citations

Association of Collagen Iα 1 Sp1 Polymorphism with the Risk of Prevalent Fractures: A Meta-Analysis

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Association of COLIA1 Sp1 Alleles with Defective Bone Nodule Formation In Vitro and Abnormal Bone Mineralization In Vivo

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Randomized trial of osteoporosis screening. Use of hormone replacement therapy and quality-of-life results

1997 • 57 citations

Common variants at the PCOL2 and Sp1 binding sites of the COL1A1 gene and their interactive effect influence bone mineral density in Caucasians

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In vitro functional assay of alleles and haplotypes of two -promoter SNPs

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Cross-calibration of dual-energy X-ray densitometers for a large, multi-center genetic study of osteoporosis

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Randomized Trial of Osteoporosis Screening

1997 • 27 citations

Genetic Studies of Osteoporosis — A Rethink Required

2005 • 14 citations