Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence

Quantifying heterogeneity in a meta‐analysis

2002 • 31,236 citations

Operating Characteristics of a Rank Correlation Test for Publication Bias

1994 • 15,160 citations

Publication bias in clinical research

1991 • 3,034 citations

Sequence Variations inPCSK9,Low LDL, and Protection against Coronary Heart Disease

2006 • 2,981 citations

Quantitative Synthesis in Systematic Reviews

1997 • 2,428 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials

2004 • 1,728 citations

Gene–environment interactions in human diseases

2005 • 1,074 citations

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

2002 • 934 citations

Genome-wide strategies for detecting multiple loci that influence complex diseases

2005 • 897 citations

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses

2005 • 624 citations

Genetic associations in large versus small studies: an empirical assessment

2003 • 595 citations

Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease

2004 • 523 citations

Why Most Published Research Findings Are False

2019 • 483 citations

Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction

2006 • 438 citations

'Racial' differences in genetic effects for complex diseases

2004 • 434 citations

Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction

1994 • 421 citations

Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66 155 cases and 91 307 controls

2006 • 406 citations

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

2005 • 372 citations

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls

2000 • 346 citations

Lipoprotein Lipase Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease

1999 • 340 citations

Large Trials vs Meta-analysis of Smaller Trials

1996 • 337 citations

Four paraoxonase gene polymorphisms in 11 212 cases of coronary heart disease and 12 786 controls: meta-analysis of 43 studies

2004 • 322 citations

Cholesteryl Ester Transfer Protein TaqIB Variant, High-Density Lipoprotein Cholesterol Levels, Cardiovascular Risk, and Efficacy of Pravastatin Treatment

2005 • 313 citations

Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

2005 • 311 citations

ACE Gene Polymorphism in Cardiovascular Disease

2000 • 303 citations

Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease

2004 • 297 citations

Blased Tests of Association: Comparisons of Allele Frequencies when Departing from Hardy-Weinberg Proportions

1999 • 265 citations

Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases

2006 • 244 citations

A road map for efficient and reliable human genome epidemiology

2006 • 241 citations

Shaking the tree: mapping complex disease genes with linkage disequilibrium

2005 • 238 citations

Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses

2001 • 185 citations

How many genes underlie the occurrence of common complex diseases in the population?

2005 • 183 citations

Distinct Heritable Patterns of Angiographic Coronary Artery Disease in Families With Myocardial Infarction

2005 • 175 citations

Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature

2005 • 168 citations

Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II

1999 • 126 citations

Interleukin 6 −174 G/C Promoter Polymorphism and Risk of Coronary Heart Disease

2005 • 104 citations

Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms

2000 • 98 citations

The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?

2004 • 95 citations

Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease

1996 • 92 citations

Genetic Variants of Angiotensin II Receptors and Cardiovascular Risk in Hypertension

2003 • 91 citations

Genetic Polymorphisms and Coronary Artery Disease in the South of France

2000 • 88 citations

APO B gene polymorphisms and coronary artery disease: a meta-analysis

2003 • 87 citations

Meta-Analysis of 4 Coronary Heart Disease Genome-Wide Linkage Studies Confirms a Susceptibility Locus on Chromosome 3q

2003 • 83 citations

Synergistic Effect between Apolipoprotein E and Angiotensinogen Gene Polymorphisms in the Risk for Early Myocardial Infarction

2000 • 75 citations

Commentary: Grading the credibility of molecular evidence for complex diseases

2006 • 68 citations

A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction

1997 • 63 citations

Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events

2002 • 61 citations

An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment

2006 • 55 citations

Angiotensin II type 1 receptor A1166C gene polymorphism Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases

1998 • 54 citations

Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease.

2003 • 54 citations

Relationship of venous thromboembolism and myocardial infarction with the renin‐angiotensin system in African‐Americans

2002 • 52 citations

Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction

2001 • 46 citations

Atherogenic, hemostatic, and other potential risk markers in subjects with previous isolated myocardial infarction compared with long-standing uncomplicated stable angina

1998 • 41 citations

Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease

2001 • 37 citations

The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction

1999 • 34 citations

Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction

2001 • 34 citations

Angiotensin II type‐I receptor and ACE polymorphisms and risk of myocardial infarction in men and women

2000 • 28 citations

Characterization of the Binding of the RNA-Binding Protein AUF1 to the Human AT1 Receptor mRNA

1999 • 23 citations

Genetic Background in Patients with Acute Myocardial Infarction.

2001 • 22 citations

How frequent is altered gene expression among susceptibility genes to human complex disorders?

2005 • 20 citations

A1166C polymorphism of the angiotensin II type 1 receptor gene and risk of adverse events after coronary catheter interventions

2000 • 13 citations

Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients

2005 • 7 citations