Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

2000 • 18,725 citations

Statistical Methods for Rates and Proportions

2003 • 17,930 citations

Operating Characteristics of a Rank Correlation Test for Publication Bias

1994 • 15,160 citations

Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles

1992 • 4,934 citations

Systematic Reviews in Health Care : Meta-Analysis in Context

2000 • 2,282 citations

The Hazards of Scoring the Quality of Clinical Trials for Meta-analysis

1999 • 1,977 citations

Explaining heterogeneity in meta-analysis: a comparison of methods

1999 • 1,666 citations

QUANTITATIVE METHODS IN THE REVIEW OF EPIDEMIOLOGIC LITERATURE1

1987 • 1,619 citations

Meta-analysis: formulating, evaluating, combining, and reporting

1999 • 958 citations

Systematic Review: Why sources of heterogeneity in meta-analysis should be investigated

1994 • 947 citations

Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine

1994 • 899 citations

Detecting and describing heterogeneity in meta-analysis

1998 • 689 citations

Meta-analysis in epidemiology, with special reference to studies of the association between exposure to environmental tobacco smoke and lung cancer: A critique

1991 • 402 citations

The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk

1997 • 400 citations

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls

2000 • 346 citations

Random-Effects Meta-Analyses Are Not Always Conservative

1999 • 325 citations

Missense mutations in the pancreatic islet beta cell inwardly rectifying K + channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1998 • 271 citations

APOE genotype as a risk factor for ischemic cerebrovascular disease

1999 • 269 citations

Blased Tests of Association: Comparisons of Allele Frequencies when Departing from Hardy-Weinberg Proportions

1999 • 265 citations

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response

1998 • 254 citations

Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders

1998 • 248 citations

How to review the evidence: systematic identification and review of the scientific literature

2000 • 238 citations

Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy

1998 • 236 citations

M235T angiotensinogen gene polymorphism and cardiovascular renal risk

1999 • 236 citations

Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk.

1995 • 214 citations

Association Between the Angiotensinogen 235T-Variant and Essential Hypertension in Whites

1997 • 195 citations

Identifying Clinical Trials in the Medical Literature with Electronic Databases

2000 • 178 citations

Meta-analysis of the ACE gene in ischaemic stroke

1998 • 174 citations

Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy

1995 • 169 citations

A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia

1998 • 167 citations

HLA class II (DR and DQ) antigen associations in idiopathic dilated cardiomyopathy. Validation study and meta-analysis of published HLA association studies.

1991 • 159 citations

Meta-Analysis of the Association of Trp64Arg Polymorphism ofβ3-Adrenergic Receptor Gene with Body Mass Index1

1998 • 154 citations

Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia

1996 • 144 citations

Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.

1999 • 141 citations

Association Between Bipolar Disorder and Monoamine Oxidase A Gene Polymorphisms: Results of a Multicenter Study

2000 • 137 citations

Review of the putative association of dopamine D2 receptor and alcoholism: A meta‐analysis

1993 • 131 citations

Meta-analysis of the association of the Trp64Arg polymorphism in the β3 adrenergic receptor with body mass index

1998 • 128 citations

CYP1A1 polymorphisms and lung cancer risk: a meta-analysis

2000 • 127 citations

Meta-analysis of DRD3 gene and schizophrenia: Ethnic heterogeneity and significant association in caucasians

1998 • 120 citations

Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson??s disease

1998 • 106 citations

Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter

1999 • 103 citations

Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.

1997 • 98 citations

Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis

2000 • 90 citations

Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies

1997 • 82 citations

Angiotensinogen gene and essential hypertension in the Japanese

1999 • 79 citations

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls

2000 • 78 citations

?141 C Del/Ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population

1999 • 70 citations

Mild association between the A/G polymorphism in the promoter of the apolipoprotein A-I gene and apolipoprotein A-I levels: A meta-analysis

1999 • 67 citations

Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet

2000 • 59 citations

Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders

1999 • 57 citations

ApoE Genotype and Alzheimer's Disease in Adults With Down Syndrome: Meta-Analysis

1997 • 53 citations

Meta-analysis by random effect modelling in generalized linear models

1999 • 51 citations

Meta-analysis of Genetic-Linkage Analysis of Quantitative-Trait Loci

2002 • 50 citations

The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: A meta- analysis

1997 • 43 citations

HLA class II gene polymorphism contributes little to Hashimoto's thyroiditis

1992 • 40 citations

Diagnostic statistical procedures in medical meta-analyses

1999 • 39 citations

18 Meta-analysis for model-free methods

2001 • 24 citations

Absence of effect of seven functional mutations in the cyp2d6 gene in Parkinson's disease

1999 • 15 citations