Mendelian randomisation: a new spin or real progress?

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

2003 • 4,975 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

A comprehensive review of genetic association studies

2002 • 1,697 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

Linkage Disequilibrium in Humans: Models and Data

2001 • 1,280 citations

Population stratification and spurious allelic association

2003 • 1,214 citations

Patterns of linkage disequilibrium in the human genome

2002 • 1,132 citations

Epidemiological methods for studying genes and environmental factors in complex diseases

2001 • 473 citations

Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR)

1997 • 358 citations

Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials

2001 • 336 citations

Testing for Population Subdivision and Association in Four Case-Control Studies

2002 • 226 citations

A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk

2001 • 173 citations

Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease

2003 • 121 citations

Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro

2001 • 106 citations

Human molecular genetics

1996 • 102 citations

THE EFFECT OF GENETIC SUSCEPTIBILITY ON CAUSAL INFERENCE IN EPIDEMIOLOGIC STUDIES

1987 • 60 citations

Potential Clinical and Economic Effects of Homocyst(e)ine Lowering

2000 • 27 citations