Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data

Regression Models and Life-Tables

1992 • 27,454 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Quantitative Synthesis in Systematic Reviews

1997 • 2,428 citations

Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection

1997 • 2,097 citations

Review papers : The statistical basis of meta-analysis

1993 • 1,221 citations

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

1997 • 899 citations

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

1998 • 725 citations

Summing up evidence: one answer is not always enough

1998 • 671 citations

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

1997 • 609 citations

Practical methodology of meta‐analyses (overviews) using updated individual patient data

1995 • 472 citations

The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

1997 • 454 citations

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

1997 • 423 citations

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation

1998 • 397 citations

Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

1998 • 342 citations

Serum HIV-1 RNA Levels and Time to Development of AIDS in the Multicenter Hemophilia Cohort Study

1996 • 322 citations

Association between CCR5 Genotype and the Clinical Course of HIV-1 Infection

1997 • 268 citations

The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression

1997 • 256 citations

Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes

1999 • 253 citations

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

1997 • 238 citations

Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-Term Nonprogressor Status in Human Immunodeficiency Virus-1–Infected Individuals

1999 • 215 citations

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains

1997 • 192 citations

The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection

1998 • 189 citations

Influence of theCCR2-V64IPolymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4

1998 • 160 citations

Early protective effect of CCR-5 Δ32 heterozygosity on HIV-1 disease progression

1997 • 144 citations

Increased frequency of CCR-5 Δ32 heterozygotes among long-term non-progressors with HIV-1 infection

1997 • 107 citations

Distinctive Effects of CCR5, CCR2, and SDF1 Genetic Polymorphisms in AIDS Progression

1998 • 106 citations

Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy

2000 • 91 citations

A 32‐bp Deletion within the CCR5 Locus Protects against Transmission of Parenterally Acquired Human Immunodeficiency Virus but Does Not Affect Progression to AIDS‐Defining Illness

1998 • 77 citations

Shorter Survival ofSDF1‐3′A/3′AHomozygotes Linked to CD4⁺T Cell Decrease in Advanced Human Immunodeficiency Virus Type 1 Infection

2000 • 72 citations

CCR2-64I Polymorphism Is Not Associated with Altered CCR5 Expression or Coreceptor Function

1999 • 68 citations

No Evidence for an Effect of the CCR5 Δ32/+ and CCR2b 64I/+ Mutations on Human Immunodeficiency Virus (HIV)‐1 Disease Progression among HIV‐1–Infected Injecting Drug Users

1999 • 60 citations

HIV-Infected Individuals With the CCR5Δ32/CCR5 Genotype Have Lower HIV RNA Levels and Higher CD4 Cell Counts in the Early Years of the Infection Than Do Patients With the Wild Type

1997 • 47 citations

Genetic polymorphism of CCR5 gene and HIV disease: The heterozygous (CCR5/Δccr5) genotype is neither essential nor sufficient for protection against disease progression

1997 • 41 citations

Chemokine Receptor CCR2b 64I Polymorphism and Its Relation to CD4 T-Cell Counts and Disease Progression in a Danish Cohort of HIV-Infected Individuals

1998 • 38 citations