Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

Quantifying heterogeneity in a meta‐analysis

2002 • 31,236 citations

Operating Characteristics of a Rank Correlation Test for Publication Bias

1994 • 15,160 citations

Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease

1959 • 14,850 citations

The Combination of Estimates from Different Experiments

1954 • 4,769 citations

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century

2002 • 1,885 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

1992 • 1,181 citations

Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction

1992 • 1,132 citations

Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases.

2000 • 960 citations

Meta‐Analysis Of Controlled Clinical Trials

2002 • 811 citations

Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review

2002 • 783 citations

Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

2002 • 643 citations

Genetic associations in large versus small studies: an empirical assessment

2003 • 595 citations

Genetics and ischaemic stroke

2000 • 394 citations

Meta-analysis of Genetic Studies in Ischemic Stroke

2004 • 385 citations

Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations

2002 • 377 citations

Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies

2003 • 336 citations

A GENERAL ESTIMATOR FOR THE VARIANCE OF THE MANTEL HAENSZEL ODDS RATIO

1986 • 307 citations

A study of twins and stroke.

1992 • 254 citations

Genetic Liability in Stroke

2002 • 232 citations

Familial History of Stroke and Stroke Risk

1997 • 204 citations

Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke

2003 • 190 citations

Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases

2000 • 187 citations

Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke

2002 • 180 citations

Meta-analysis of the ACE gene in ischaemic stroke

1998 • 174 citations

Dose-Related Association of MTHFR 677T Allele With Risk of Ischemic Stroke

2005 • 170 citations

The role of apolipoprotein E in Alzheimer’s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models

2000 • 169 citations

Does Apolipoprotein E Genotype Influence the Risk of Ischemic Stroke, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage?

2005 • 163 citations

Methylenetetrahydrofolate Reductase Gene Polymorphism and Ischemic Stroke in Japanese

1998 • 145 citations

Parental History of Cardiovascular Disease and Risk of Stroke

1997 • 140 citations

Genetic Association Studies in Stroke

2005 • 140 citations

A Mutation in Plasma Platelet-Activating Factor Acetylhydrolase (Val ²⁷⁹ →Phe) is a Genetic Risk Factor for Stroke

1997 • 138 citations

Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.

1991 • 128 citations

Polymorphism of the Lipoprotein Lipase Gene and Risk of Atherothrombotic Cerebral Infarction in the Japanese

2001 • 103 citations

Age-Dependent Association of Apolipoprotein E Genotypes With Stroke Subtypes in a Japanese Rural Population

2000 • 103 citations

Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan

2005 • 103 citations

Polymorphism of the Methionine Synthase Gene

1999 • 99 citations

MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study

2004 • 96 citations

C242T Polymorphism of NADPH Oxidase p22 PHOX Gene and Ischemic Cerebrovascular Disease in the Japanese Population

2000 • 95 citations

Association of Phosphodiesterase 4D Gene With Ischemic Stroke in a Pakistani Population

2005 • 92 citations

Polymorphism of Angiotensin Converting Enzyme, Angiotensinogen, and Apolipoprotein E Genes in a Japanese Population With Cerebrovascular Disease

1997 • 87 citations

Gene Polymorphisms of Homocysteine Metabolism-Related Enzymes in Chinese Patients with Occlusive Coronary Artery or Cerebral Vascular Diseases

2001 • 86 citations

Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke

2006 • 85 citations

The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis

2005 • 80 citations

Polymorphism in the Promoter of Lipopolysaccharide Receptor CD14 and Ischemic Cerebrovascular Disease

2000 • 75 citations

Association Between Platelet Glycoprotein Ibα Genotype and Ischemic Cerebrovascular Disease

2000 • 70 citations

Apolipoprotein E and the Response of the Brain to Injury

1999 • 67 citations

A prospectively planned cumulative meta-analysis applied to a series of concurrent clinical trials

1997 • 64 citations

Functional effects of NAD(P)H oxidase p22phox C242T mutation in human leukocytes and association with thrombotic cerebral infarction

2004 • 64 citations

Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-α genes, but not the interleukin-1β gene

2004 • 62 citations

Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients

2001 • 62 citations

Polymorphism of the angiotensin-converting enzyme (ACE) gene in patients with thrombotic brain infarction

1997 • 60 citations

Pentanucleotide TTTTA Repeat Polymorphism of Apolipoprotein(a) Gene and Plasma Lipoprotein(a) Are Associated With Ischemic and Hemorrhagic Stroke in Chinese

2003 • 57 citations

Genotype and Haplotype Association Study of the STRK1 Region on 5q12 Among Japanese

2005 • 54 citations

Genetic influences on outcome following acute neurological insults

2005 • 52 citations

Genetic variation in the promoter region of the ??-fibrinogen gene is associated with ischemic stroke in a Japanese population

1998 • 50 citations

Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions

2003 • 49 citations

Association of interleukin-1 alpha gene polymorphism with cerebral infarction

2003 • 49 citations

TNF-α and TNF-β Gene Polymorphisms in Cerebral Infarction

2003 • 48 citations

Apolipoprotein E Genetic Polymorphism and Stroke Subtypes in a Bangladeshi Hospital-Based Study.

2001 • 39 citations

Apolipoprotein E Polymorphism in Ischemic Cerebrovascular Diseases and Vascular Dementia Patients in Taiwan

2004 • 39 citations

Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke: sex difference in Japanese.

2001 • 36 citations

4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke

2003 • 36 citations

The Sma I Polymorphism in the von Willebrand Factor Gene Associated with Acute Ischemic Stroke

2001 • 34 citations

Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction

2004 • 34 citations

Paraoxonase1 polymorphism Leu-Met55 is associated with cerebral infarction in Japanese population.

2003 • 32 citations

Apolipoprotein E gene polymorphism in cerebrovascular disease: a case–controlstudy

2002 • 32 citations

Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients

1999 • 31 citations

Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population.

2004 • 31 citations

Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke

2004 • 29 citations

Plasminogen activator inhibitor-1 4G/5G gene polymorphism in patients with myocardial or cerebrovascular infarction in Tianjin, China.

2003 • 27 citations

Helicobacter pylori infection and the CD14 C(−260)T gene polymorphism in ischemic stroke

2005 • 27 citations

Platelet glycoprotein Ia C807T, Ib C3550T, and IIIa PlA1/A2 polymorphisms and ischemic stroke in young Taiwanese

2004 • 26 citations

Polymorphism of Angiotensin-Converting Enzyme, Angiotensinogen, and Apolipoprotein E Genes in Korean Patients with Cerebral Infarction

2003 • 26 citations

Methylenetetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage

2005 • 23 citations

Notch3 gene polymorphism and ischaemic cerebrovascular disease

2002 • 23 citations

Interleukin-1 gene cluster polymorphisms in cerebral infarction

2003 • 22 citations

beta-fibrinogen gene -455A/G polymorphism and plasma fibrinogen level in Chinese stroke patients.

2002 • 22 citations

The lipoprotein lipase Ser447Ter mutation and risk of stroke in the Chinese

2003 • 21 citations

[Polymorphisms of ACE-1 and MTHFR genes and genetic susceptibility of ischemic stroke].

2002 • 20 citations

Polymorphisms in the gene encoding angiotensin 1-converting enzyme and relationship to its post-translational product in cerebral infarction.

1994 • 18 citations

Polymorphism of the Angiotensin-Converting Enzyme Gene

2001 • 17 citations

Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients

2002 • 17 citations

The 825C/T polymorphism of G-protein beta3 subunit gene and risk of ischaemic stroke

2005 • 17 citations

Apolipoprotein H Gene Polymorphisms and Risk of Primary Cerebral Hemorrhage in a Chinese Population

2003 • 17 citations

Polymorphisms of the coagulation factor VII gene and its plasma levels in relation to acute cerebral infarction differences in allelic frequencies between Chinese Han and European populations.

2004 • 14 citations

[Association of estrogen receptor gene polymorphism with cerebral infarction, a case-control study].

2002 • 11 citations

Gene Polymorphism of Platelet Glycoprotein I bα in Chinese Patients with Large- and Small-Artery Subtypes of Ischemic Stroke

2005 • 8 citations

[Relationship between polymorphisms of cystathionine beta-synthase gene and stroke].

2004 • 4 citations

[The relationship of apolipoprotein H G1025C (Try316Ser) polymorphism with stroke and its effect on plasma lipid levels in Changsha Hans].

2003 • 3 citations