APC, Signal transduction and genetic instability in colorectal cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Pathologic Basis of Disease.

1980 • 4,790 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Cancer statistics, 2000

2000 • 3,907 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

How cells read TGF-β signals

2000 • 1,843 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

Estimates of the worldwide mortality from 25 cancers in 1990

1999 • 1,494 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

1999 • 807 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

1998 • 722 citations

Mutations in the APC tumour suppressor gene cause chromosomal instability

2001 • 722 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

1999 • 665 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Pathologic Basis of Disease

1985 • 631 citations

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

2001 • 626 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Aberrant Crypt Foci of the Colon as Precursors of Adenoma and Cancer

1998 • 591 citations

Role of aberrant crypt foci in understanding the pathogenesis of colon cancer

1995 • 578 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

2001 • 553 citations

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

2001 • 532 citations

Errors in DNA replication as a basis of malignant changes.

1974 • 527 citations

Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway

1999 • 513 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

2000 • 491 citations

APC mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”

2000 • 486 citations

Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover

2000 • 472 citations

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

1999 • 452 citations

APC binds to the novel protein EB1.

1995 • 450 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

1998 • 432 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

2000 • 401 citations

Mutations of theAPC adenomatous polyposis coli) gene

1993 • 392 citations

The onset and extent of genomic instability in sporadic colorectal tumor progression

1999 • 388 citations

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.

2001 • 383 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1999 • 373 citations

Top-down morphogenesis of colorectal tumors

2001 • 370 citations

Opposing Effects of Ras on p53

2000 • 361 citations

The APC tumour suppressor has a nuclear export function

2000 • 348 citations

Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer

1998 • 343 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

1999 • 309 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Nuclear Overexpression of the Oncoprotein β-Catenin in Colorectal Cancer is Localized Predominantly at the Invasion Front

1998 • 296 citations

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.

1994 • 286 citations

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

2000 • 284 citations

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

1999 • 267 citations

Eb1 Proteins Regulate Microtubule Dynamics, Cell Polarity, and Chromosome Stability

2000 • 265 citations

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice

2000 • 241 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

1999 • 237 citations

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.

1999 • 227 citations

K-ras Mutations in Putative Preneoplastic Lesions in Human Colon

1993 • 224 citations

Mechanisms underlying losses of heterozygosity in human colorectal cancers

2001 • 221 citations

Overexpression of β-Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators

2000 • 203 citations

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.

1999 • 202 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

2000 • 187 citations

Apoptosis induced by overexpression of hMSH2 or hMLH1.

1999 • 178 citations

GSK-3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin

2000 • 177 citations

Mismatch repair, molecular switches, and signal transduction

1998 • 176 citations

Expression of Nuclear β-Catenin and c-myc Is Correlated with Tumor Size but Not with Proliferative Activity of Colorectal Adenomas

2000 • 166 citations

Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

1988 • 157 citations

Restricted High Level Expression of Tcf-4 Protein in Intestinal and Mammary Gland Epithelium

1999 • 153 citations

β-TrCP is a negative regulator of the Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos

1998 • 152 citations

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).

1993 • 149 citations

Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma

1988 • 147 citations

Immunohistochemical study of epithelial cell proliferation in hyperplastic polyps, adenomas, and adenocarcinomas of the large bowel

1988 • 141 citations

How aneuploidy affects metabolic control and causes cancer

1999 • 137 citations

C-myc overexpression and p53 loss cooperate to promote genomic instability

1999 • 137 citations

Axin prevents Wnt-3a-induced accumulation of β-catenin

1999 • 134 citations

Signaling mismatch repair in cancer

1999 • 133 citations

c-Myc Overexpression Uncouples DNA Replication from Mitosis

1999 • 128 citations

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

1998 • 126 citations

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

2000 • 121 citations

Proliferation and apoptosis in proliferative lesions of the colon and rectum

1997 • 117 citations

Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours

1997 • 116 citations

A model of DNA aneuploidization and evolution in colorectal cancer.

1994 • 105 citations

APC EXPRESSION IN NORMAL HUMAN TISSUES

1997 • 103 citations

Immunohistochemical analysis of cell kinetic parameters in colonic adenocarcinomas, adenomas, and normal mucosa

1989 • 102 citations

Lynch syndrome: genetics, natural history, genetic counseling, and prevention.

2000 • 98 citations

SomaticApc mutations are selected upon their capacity to inactivate the ?-catenin downregulating activity

2000 • 95 citations

Disease model: familial adenomatous polyposis

2001 • 92 citations

BRCA1 and cell signaling

2000 • 88 citations

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule‐associated protein tau

1998 • 84 citations

Nuclear Export of Human β-Catenin Can Occur Independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppressor

2001 • 74 citations

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

2000 • 70 citations

Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.

1996 • 69 citations

Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

1999 • 62 citations

Axin and hepatocellular carcinomas

2000 • 58 citations

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

2000 • 54 citations

Distribution of cells expressing myc proteins in human colorectal epithelium, polyps, and malignant tumors.

1992 • 51 citations

K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas

1995 • 49 citations

Colorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patients.

1997 • 46 citations

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

1997 • 40 citations

Specific K-ras2 Mutations in Human Sporadic Colorectal Adenomas Are Associated with DNA Near-Diploid Aneuploidy and Inhibition of Proliferation

1998 • 38 citations

Transfection of human mutated K-ras in mouse NIH-3T3 cells is associated with increased cloning efficiency and DNA aneuploidization

1996 • 23 citations

Ki-ras activationin vitro affects G1 and G2M cell-cycle transit times and apoptosis

2000 • 12 citations

Oncogene Expression in Patients with Familial Polyposis coli/Gardner’s Syndrome

1996 • 5 citations