Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Molecular Beacons: Probes that Fluoresce upon Hybridization

1996 • 4,073 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Digital PCR

1999 • 1,585 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Multicolor molecular beacons for allele discrimination

1998 • 1,322 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Natural history of untreated colonic polyps

1987 • 948 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Clonal Origin of Bladder Cancer

1992 • 538 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Cancer of the microsatellite mutator phenotype.

1996 • 226 citations

Clonal Expansion and Loss of Heterozygosity at Chromosomes 9p and 17p in Premalignant Esophageal (Barrett's) Tissue

1999 • 219 citations

Aneuploidy, the somatic mutation that makes cancer a species of its own

2000 • 214 citations

Microallelotyping defines the sequence and tempo of alleiic losses at tumour suppressor gene loci during colorectal cancer progression

1995 • 195 citations

APC mutations are sufficient for the growth of early colorectal adenomas

2000 • 182 citations

Flow cytometric detection of aneuploidy in colorectal adenomas.

1985 • 139 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Inherited susceptibility to colorectal adenomas and carcinomas: Evidence for a new predisposition gene on 15q14-q22

1999 • 109 citations

A model of DNA aneuploidization and evolution in colorectal cancer.

1994 • 105 citations

Deletion of 1p loci and microsatellite instability in colorectal polyps

1995 • 98 citations

Loss of Heterozygosity in Fibrocystic Change of the Breast

2000 • 78 citations

Allelic Imbalance in Lichen Sclerosus, Hyperplasia, and Intraepithelial Neoplasia of the Vulva

2000 • 78 citations

Counting alleles reveals a connection between chromosome 18q loss and vascular invasion

2001 • 72 citations

Genetic instability in intestinal metaplasia is a frequent event leading to well-differentiated early adenocarcinoma of the stomach

2000 • 61 citations

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice

1998 • 61 citations

DNA flow cytometry of endoscopically examined colorectal adenomas and adenocarcinomas

1988 • 54 citations

Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro

1998 • 52 citations

DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.

2000 • 45 citations

Loss of heterozygosity in tumor cells requires re‐evaluation: the data are biased by the size‐dependent differential sensitivity of allele detection

1999 • 43 citations

Deletion analysis of chromosome 8p in sporadic colorectal adenomas

1994 • 22 citations

HeterozygousAprt mouse model: Detection and study of a broad range of autosomal somatic mutations in vivo

1999 • 12 citations

K-ras2 Activation and Genome Instability Increase Proliferation and Size of FAP Adenomas

1999 • 4 citations

K‐ras2 Mutation Spectrum, DNA Aneuploidy, and Epithelial Cell Proliferation in Colorectal Adenomas^a

1995 • 2 citations