E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications

1983 • 1,856 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Ackerman's surgical pathology

1974 • 1,070 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation

1999 • 526 citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

1994 • 519 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Cell adhesion: old and new questions

1999 • 426 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Loss of Apc+ in intestinal adenomas from Min mice.

1994 • 373 citations

Uncoupling cadherin-based adhesion from wingless signalling in Drosophila

1996 • 365 citations

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis

1997 • 341 citations

Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

1998 • 330 citations

Germline E-cadherin Gene (CDH1) Mutations Predispose to Familial Gastric Cancer and Colorectal Cancer

1999 • 325 citations

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.

1996 • 322 citations

The APC Protein and E-cadherin Form Similar but Independent Complexes with α-Catenin, β-Catenin, and Plakoglobin

1995 • 315 citations

Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis.

1996 • 300 citations

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.

1996 • 292 citations

Inactivation of both APC alleles in human and mouse tumors.

1994 • 248 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

1999 • 237 citations

Inhibition of β-catenin-mediated transactivation by cadherin derivatives

1998 • 217 citations

E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas.

1999 • 149 citations

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).

1993 • 149 citations

Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

1993 • 137 citations

E‐Cadherin Gene Mutations in Signet Ring Cell Carcinoma of the Stomach

1996 • 135 citations

Apc1638N: A mouse model for familial adenomatous polyposis–associated desmoid tumors and cutaneous cysts

1998 • 133 citations

Inactivation of the E‐Cadherin Gene in Primary Gastric Carcinomas and Gastric Carcinoma Cell Lines

1996 • 111 citations

The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis

1993 • 109 citations

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis

1997 • 107 citations

Single-cell mutation analysis of tumors from stained histologic slides.

1996 • 106 citations

A possible new adhesive site in the cell-adhesion molecule uvomorulin

1990 • 102 citations

SomaticApc mutations are selected upon their capacity to inactivate the ?-catenin downregulating activity

2000 • 95 citations

E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas

1999 • 83 citations

Adhesion Receptors in Malignant Transformation and Dissemination of Gastrointestinal Tumors

1996 • 72 citations

Frequent Somatic Allelic Inactivation of the E-cadherin Gene in Gastric Carcinomas

1995 • 52 citations

L‐Cam expression in normal, premalignant, and malignant colon mucosa

1992 • 52 citations

Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors

1996 • 36 citations

Loss of immunohistochemical E-cadherin expression in colon cancer is not due to structural gene alterations

1999 • 36 citations

Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays

1997 • 33 citations

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in theApc1638N mouse model

1999 • 31 citations

Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer

1999 • 24 citations

Cadherin adhesion in the intestinal crypt regulates morphogenesis, mitogenesis, motogenesis, and metaplasia formation

1999 • 7 citations