Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

Gardner syndrome in a man with an interstitial deletion of 5q

1986 • 458 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

1990 • 386 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

1992 • 257 citations

Association between wild type and mutant APC gene products.

1993 • 194 citations

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 182 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Allele-specific polymerase chain reaction: A method for amplification and sequence determination of a single component among a mixture of sequence variants

1991 • 163 citations

Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.

1993 • 152 citations

Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.

1993 • 139 citations

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)

1992 • 120 citations

High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22.

1989 • 117 citations

Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma.

1989 • 81 citations

Azacytidine-induced tumorigenesis of CHEF/18 cells: correlated DNA methylation and chromosome changes.

1983 • 80 citations

Chromosome 5 allele loss in familial and sporadic colorectal adenomas

1989 • 43 citations