Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders

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1993 • 11,303 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

STRESS AND HIPPOCAMPAL PLASTICITY

1999 • 2,023 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Stress and cognitive function

1995 • 1,830 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

1995 • 1,429 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

NEUROTROPHINS AND SYNAPTIC PLASTICITY

1999 • 1,343 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

Co‐operative action of calcium ions in transmitter release at the neuromuscular junction

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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

1993 • 1,302 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

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Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

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Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Current advances and trends in the treatment of depression

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Hippocampal damage associated with prolonged glucocorticoid exposure in primates

1990 • 1,092 citations

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

1998 • 1,045 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews

1996 • 849 citations

Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)

1997 • 829 citations

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function

1995 • 812 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Modulation of ion-channel function by G-protein-coupled receptors

1994 • 764 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists

1996 • 656 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Neurotrophins and depression

1999 • 538 citations

Synapsins as regulators of neurotransmitter release

1999 • 532 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

Modulation of ION Channels by Protein Phosphorylation and Dephosphorylation

1994 • 530 citations

cAMP-Dependent Regulation of Cardiac L-Type Ca2+ Channels Requires Membrane Targeting of PKA and Phosphorylation of Channel Subunits

1997 • 511 citations

The CaM kinase II hypothesis for the storage of synaptic memory

1994 • 510 citations

Dual role of calmodulin in autophosphorylation of multifunctional cam kinase may underlie decoding of calcium signals

1994 • 508 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) and Related Transcription-Activating Deoxyribonucleic Acid-Binding Proteins*

1993 • 476 citations

The postsynaptic density at glutamatergic synapses

1997 • 474 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice

1999 • 463 citations

Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl-d-aspartate Receptor

1998 • 442 citations

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

1996 • 439 citations

Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

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Protein Phosphorylation and Signal Transduction

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Functional impact of syntaxin on gating of N-type and Q-type calcium channels

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Stress: metaplastic effects in the hippocampus

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Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.

1993 • 402 citations

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

1995 • 391 citations

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Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

1994 • 371 citations

Presynaptic inhibition in the hippocampus

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Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2.

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Enhancement of Neurotransmitter Release Induced by Brain-Derived Neurotrophic Factor in Cultured Hippocampal Neurons

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1997 • 309 citations

Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus

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Inhibition of neuronal Na+ channels by antidepressant drugs.

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Abnormal Fear Response and Aggressive Behavior in Mutant Mice Deficient for α-Calcium-Calmodulin Kinase II

1994 • 292 citations

A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP.

1994 • 291 citations

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

1994 • 286 citations

Serotonin and the Neurobiology of Depression

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Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes

1990 • 284 citations

Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes

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1996 • 273 citations

Protein Kinase A Anchoring

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Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain

1989 • 261 citations

The effect on synaptic physiology of synaptotagmin mutations in drosophila

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Phosphorylation of 25-kDa Synaptosome-associated Protein

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Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins

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Novel therapeutic approaches beyond the serotonin receptor

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More on target with protein phosphorylation: conferring specificity by location.

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Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.

1990 • 203 citations

Lithium and brain signal transduction systems

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Chronic Antidepressant Administration Alters the Subcellular Distribution of Cyclic AMP‐Dependent Protein Kinase in Rat Frontal Cortex

1989 • 196 citations

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1992 • 192 citations

Regulation of Exocytosis by Cyclin-dependent Kinase 5 via Phosphorylation of Munc18

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Increased Platelet Intracellular Calcium Concentration in Patients With Bipolar Affective Disorders

1989 • 184 citations

Fast actions of neurotrophic factors

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Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

1990 • 165 citations

Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons

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Phosphorylation of the Synaptic Protein Interaction Site on N-type Calcium Channels Inhibits Interactions with SNARE Proteins

1997 • 154 citations

Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

1992 • 139 citations

alpha KAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle

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The RII subunit of camp-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C

1989 • 130 citations

Neurobiology of lithium: an update.

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1991 • 115 citations

Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers

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1991 • 110 citations

cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment

1989 • 102 citations

Identification of two subclasses of type II cAMP-dependent protein kinases. Neural-specific and non-neural protein kinases.

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Regulation of Synaptotagmin I Phosphorylation by Multiple Protein Kinases

1999 • 101 citations

Generation of the Ca2+-independent form of Ca2+/calmodulin-dependent protein kinase II in cerebellar granule cells

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The role of Ca2+/calmodulin-dependent protein kinases within the nucleus

1998 • 99 citations

Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells.

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SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis.

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A Novel Protein Phosphatase That Dephosphorylates and Regulates Ca2+/Calmodulin-dependent Protein Kinase II

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Calmodulin‐dependent protein kinase II mediates signal transduction in apoptosis

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1988 • 81 citations

Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content.

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Effects of chronic lithium treatment on protein kinase c and cyclic AMP-dependent protein phosphorylation

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Nicotinic Acetylcholine Receptor Antagonistic Activity of Monoamine Uptake Blockers in Rat Hippocampal Slices

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1991 • 72 citations

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Structure and Regulation of Type II Calcium/Calmodulin-dependent Protein Kinase in Central Nervous System Neurons

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Lithium Increases Tyrosine Hydroxylase Levels Both In Vivo and In Vitro

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Abnormalities of cAMP signaling in affective disorders: implications for pathophysiology and treatment

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Synaptotagmin is endogenously phosphorylated by Ca²⁺/calmodulin protein kinase II in synaptic vesicles

1993 • 62 citations

Brain-derived Neurotrophic Factor Increases Ca2+/Calmodulin-dependent Protein Kinase 2 Activity in Hippocampus

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Changes of Synaptotagmin Interaction with t‐SNARE Proteins In Vitro After Calcium/Calmodulin‐Dependent Phosphorylation

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Critical issues in the treatment of affective disorders

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Multiple Forms and Distribution of Calcium/Calmodulin‐Stimulated Protein Kinase II in Brain

1992 • 55 citations

Global Forebrain Ischemia Induces a Posttranslational Modification of Multifunctional Calcium‐ and Calmodulin‐Dependent Kinase II

1992 • 54 citations

Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments

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5 Calcium-dependent protein kinases in learning and memory

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Chronic Administration of Lithium or Other Antidepressants Increases Levels of DARPP‐32 in Rat Frontal Cortex

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New perspectives on the molecular pharmacology of affective disorders

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Intracellular calcium signaling systems in the pathophysiology of affective disorders

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Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders

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Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock

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Changes in the regulation of 5-hydroxytryptamine release by α2-adrenoceptors in the rat hippocampus after long-term desipramine treatment

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Long Term Blockade of Serotonin Reuptake Affects Synaptotagmin Phosphorylation in the Hippocampus

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Effects of Lithium on cAMP-Dependent Protein Kinase in Rat Brain

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Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine.

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cAMP-dependent phosphorylation system after short and long-term administration of moclobemide

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Biochemical and functional characterization of the synaptic vesicle-associated form of Ca 2+ /calmodulin-dependent protein kinase II

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Effects of long-term treatment with desipramine on microtubule proteins in rat cerebral cortex

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Effects of imipramine and sertraline on protein kinase activity in rat frontal cortex

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Inhibitory effect of lithium on cAMP dependent phosphorylation system

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Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules

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Antidepressants and protein kinases: Inhibition of Ca2+-regulated myosin phosphorylation by fluoxetine and iprindole

1986 • 24 citations

Antidepressants inhibit spontaneous oscillations of intracellular Ca2+ concentration in rat cortical cultured neurons

1992 • 24 citations

The effect of prolonged imipramine and electroconvulsive shock treatment on calcium/calmodulin-dependent protein kinase II in the hippocampus of rat brain

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Atypical antidepressants inhibit depolarization-induced calcium uptake in rat hippocampus synaptosomes

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Chronic Imipramine Administration Alters the Activity and Phosphorylation State of Tyrosine Hydroxylase in Dopaminergic Regions of Rat Brain

1995 • 22 citations

Corticotropin-Releasing Factor Antagonists

1999 • 20 citations

Phosphorylation and activation of Ca²⁺/calmodulin‐dependent protein kinase phosphatase by Ca²⁺/calmodulin‐dependent protein kinase II

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Modifications in Brain CaM Kinase II after Long-Term Treatment with Desmethylimipramine

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Antidepressants and protein kinases: Desipramine treatment affects pineal gland cAMP-dependent protein kinase activity

1986 • 17 citations

Ca2+/phospholipid-binding and syntaxin-binding of native synaptotagmin I

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Modifications in brain cAMP- and calcium/calmodulin-dependent protein kinases induced by treatment with S-adenosylmethionine

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Inhibitory effect of imipramine on depolarization-induced increases in intracellular Ca2+ of rat cortical neurons

1994 • 14 citations

Evidence for the existence of cAMP-dependent protein kinase phosphorylation system associated with specific phosphoproteins in stable microtubules from rat cerebral cortex

1993 • 13 citations

Time-course changes in rat cerebral cortex subcellular distribution of the cyclic-AMP binding after treatment with selective serotonin reuptake inhibitors

1998 • 12 citations

Perinuclear Membrane Localization of KAP, a Protein Produced from a Gene within the Gene of Calmodulin-Dependent Protein Kinase II

1997 • 5 citations