Protein Phosphorylation and Signal Transduction

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Apoptosis by Death Factor

1997 • 5,038 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

1979 • 540 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

CONVERSION OF PHOSPHORYLASE b TO PHOSPHORYLASE a IN MUSCLE EXTRACTS

1955 • 496 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1957 • 486 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

The phosphorylase b to a converting enzyme of rabbit skeletal muscle

1956 • 463 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Factors Affecting the Activity of Muscle Phosphorylase b Kinase

1959 • 418 citations

The Regulation of Skeletal Muscle Phosphorylase Kinase by Ca2+

1971 • 416 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

1998 • 378 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Cyclic Nucleotide-dependent Protein Kinases

1970 • 334 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

Emerging from the Pak: the p21-activated protein kinase family

1997 • 285 citations

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

1997 • 285 citations

An Adenosine 3′,5′-Monophosphate-dependent Protein Kinase from Escherichia coli

1969 • 266 citations

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1997 • 257 citations

T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation

1997 • 254 citations

Actin cleavage by CPP-32/apopain during the development of apoptosis

1997 • 251 citations

EFFECT OF HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR AND EPINEPHRINE ON LIVER PHOSPHORYLASE

1951 • 247 citations

CRYSTALLINE MUSCLE PHOSPHORYLASE

1943 • 244 citations

Activation of Skeletal Muscle Phosphorylase b Kinase by CA^{2+ *}

1964 • 240 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1956 • 218 citations

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1996 • 217 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite

1996 • 211 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

THE ENZYMATIC CONVERSION OF PHOSPHORYLASE a TO b

1945 • 190 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase

1997 • 173 citations

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

1996 • 166 citations

THE MECHANISM OF EPINEPHRINE ACTION

1928 • 151 citations

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro

1997 • 147 citations

CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.

1996 • 130 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

Specific Proteolysis of the Kinase Protein Kinase C-related Kinase 2 by Caspase-3 during Apoptosis

1997 • 103 citations

Protein Serine/Threonine Kinases of the MAPK Cascade

1995 • 86 citations

THE MECHANISM OF EPINEPHRINE ACTION

1928 • 76 citations

A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

1997 • 75 citations

CrmA/SPI-2 Inhibition of an Endogenous ICE-related Protease Responsible for Lamin A Cleavage and Apoptotic Nuclear Fragmentation

1996 • 72 citations

A Comparison of Signaling Requirements for Apoptosis of Human B Lymphocytes Induced by the B Cell Receptor and CD95/Fas

1998 • 68 citations

THE MECHANISM OF EPINEPHRINE ACTION

1928 • 40 citations